Collagenous sprue cross-sectional imaging: a comparative blinded study

• Published in: Abdominal imaging 2017-02, Vol.42 (2), p.396-402
• Main Authors: Al-Bawardy, Badr, Sheedy, Shannon P., Herberts, Michelle B., Murray, Joseph A., Rubio-Tapia, Alberto, Rajan, Elizabeth, Bruining, David H., Hansel, Stephanie L., Barlow, John M., Fletcher, Joel G., Fidler, Jeff L.
• Format: Article
• Language: English
• Subjects: Case-Control Studies; Collagenous Sprue - diagnostic imaging; Collagenous Sprue - pathology; Female; Gastroenterology; Hepatology; Humans; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Radiology; Retrospective Studies
• ISSN: 2366-004X; 2366-0058
• DOI: 10.1007/s00261-016-1007-1

Purpose Collagenous sprue (CS) is a rare enteropathy characterized by villous atrophy and a thickened subepithelial collagen band. The aim of this study is to describe the cross-sectional imaging findings of CS. Methods A case–control, retrospective study with cases of all CS patients from January 2000 to 2015 was performed. Inclusion criteria were (1) Histopathologic diagnosis and (2) Imaging with computed tomography abdomen/pelvis (CT A/P), CT enterography (CTE), or magnetic resonance enterography within 6 months of small bowel (SB) biopsy. Control subjects were irritable bowel syndrome (IBS) patients who underwent CTE. Imaging studies were examined by two GI radiologists, blinded to patient data. Results 108 patients (54 CS; 54 IBS) were included. Mean age was 56.7 ± 16.5 years, and 68% were female (72% in CS group vs. 63% in IBS group; p  = 0.3). CS patients were significantly older (67 ± 12 vs. 47 ± 15 year; p