Breast Malignancies in Children: Presentation, Management, and Survival

Purpose Pediatric breast malignancies are rare, and descriptions in the literature are limited. The purpose of our study was to compare pediatric and adult breast malignancy. Methods We performed a retrospective cohort study using the National Cancer Data Base comparing patients ≤21 years to those &...

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Bibliographic Details
Published in:Annals of surgical oncology 2017-06, Vol.24 (6), p.1482-1491
Main Authors: Richards, Morgan K., Goldin, Adam B., Beierle, Elizabeth A., Doski, John J., Goldfarb, Melanie, Langer, Monica, Nuchtern, Jed G., Vasudevan, Sanjeev, Gow, Kenneth W., Javid, Sara H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Aged
Aged, 80 and over
Breast
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Breast Oncology
Carcinoma, Ductal, Breast - diagnosis
Carcinoma, Ductal, Breast - mortality
Carcinoma, Ductal, Breast - therapy
Carcinoma, Lobular - diagnosis
Carcinoma, Lobular - mortality
Carcinoma, Lobular - therapy
Child
Child, Preschool
Children
Combined Modality Therapy
Disease Management
Female
Follow-Up Studies
Generalized linear models
Humans
Infant
Infant, Newborn
Invasiveness
Malignancy
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Nodes
Oncology
Pediatrics
Prognosis
Regression analysis
Retrospective Studies
Sarcoma
Sarcoma - diagnosis
Sarcoma - mortality
Sarcoma - therapy
Surgery
Surgical Oncology
Survival
Survival Rate
Young Adult
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Summary:Purpose Pediatric breast malignancies are rare, and descriptions in the literature are limited. The purpose of our study was to compare pediatric and adult breast malignancy. Methods We performed a retrospective cohort study using the National Cancer Data Base comparing patients ≤21 years to those >21 years at diagnosis (1998–2012). Generalized linear models estimated differences in demographic, tumor, and treatment characteristics. Cox regression was used to compare overall survival. Results Of 1,999,181 cases of invasive breast malignancies, 477 (0.02%) occurred in patients ≤21 years. Ninety-nine percent of adult patients had invasive carcinoma compared with 64.8% of pediatric patients with the remaining patients having sarcoma, malignant phyllodes, or malignancy not otherwise specified ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-016-5747-5