CD44 enhances macrophage phagocytosis and plays a protective role in Streptococcus equi subsp. zooepidemicus infection

•CD44 promotes the recruitment of macrophages to infect lungs.•CD44 deficiency impairs the binding of S. zooepidemicus to macrophage.•CD44 deficiency increased bacterial outgrowth and dissemination. Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an important pathogen associated with a...

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Bibliographic Details
Published in:Veterinary microbiology 2017-01, Vol.198, p.121-126
Main Authors: Fu, Qiang, Wei, Zigong, Xiao, Pingping, Chen, Yaosheng, Liu, Xiaohong
Format: Article
Language:English
Subjects:
Adaptive immunity
Alveoli
Animal diseases
Animals
Bacteria
Bronchus
CD44
CD44 antigen
Horse Diseases - genetics
Horse Diseases - immunology
Horses
Hyaluronan Receptors - genetics
Hyaluronan Receptors - metabolism
Immune response
Immunity - genetics
Infections
Macrophages
Macrophages - immunology
Macrophages - microbiology
Mice
Pathogens
Phagocytosis
Phagocytosis - genetics
Phagocytosis - immunology
Streptococcal Infections - genetics
Streptococcal Infections - immunology
Streptococcal Infections - veterinary
Streptococcus
Streptococcus equi - physiology
Streptococcus equi subsp. zooepidemicus
Survival Analysis
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Summary:•CD44 promotes the recruitment of macrophages to infect lungs.•CD44 deficiency impairs the binding of S. zooepidemicus to macrophage.•CD44 deficiency increased bacterial outgrowth and dissemination. Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is an important pathogen associated with a wide range of diseases in many mammalian species. CD44 is a transmembrane adhesion molecule involved in innate and adaptive immune responses. The aim of this study was to determine the protective role of CD44 during S. zooepidemicus infection. CD44-deficient mice exhibited reduced macrophage accumulation in the bronchoalveolar space and enhanced bacterial outgrowth and dissemination, which resulted in reduced mouse survival. An in vitro analysis revealed that CD44 can directly bind to S. zooepidemicus. Additionally, S. zooepidemicus interacted with macrophage-associated CD44, as reflected by the reduced uptake of S. zooepidemicus by CD44-deficient macrophages. These data suggest that CD44 contributes to effective antibacterial defense during S. zooepidemicus infection, thereby limiting the accompanying injury and death.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2016.12.030