Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design

New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex c...

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Bibliographic Details
Published in:Cell stem cell 2017-01, Vol.20 (1), p.13-17
Main Authors: Lipsitz, Yonatan Y., Bedford, Patrick, Davies, Anthony H., Timmins, Nicholas E., Zandstra, Peter W.
Format: Article
Language:English
Subjects:
Artificial Cells - cytology
Cell Engineering
Cell- and Tissue-Based Therapy - standards
Humans
Social Control, Formal
Translational Medical Research
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Summary:New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ultimately increasing patient access to living therapeutics. New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ultimately increasing patient access to living therapeutics.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2016.12.003