Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea

Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum...

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Bibliographic Details
Published in:Multiple sclerosis 2017-11, Vol.23 (13), p.1748-1756
Main Authors: Seok, Jin Myoung, Cho, Hye-Jin, Ahn, Suk-Won, Cho, Eun Bin, Park, Min Su, Joo, In-Soo, Shin, Ha Young, Kim, Sun-Young, Kim, Byung-Jo, Kim, Jong Kuk, Cho, Joong-Yang, Huh, So-Young, Kwon, Ohyun, Lee, Kwang-Ho, Kim, Byoung Joon, Min, Ju-Hong
Format: Article
Language:English
Subjects:
Adult
Age
Age of Onset
Aquaporin 4
Aquaporin 4 - immunology
Autoantibodies - blood
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging
Neuromyelitis
Neuromyelitis Optica - blood
Neuromyelitis Optica - epidemiology
Neuromyelitis Optica - pathology
Neuromyelitis Optica - physiopathology
NMR
Nuclear magnetic resonance
Optic nerve
Republic of Korea - epidemiology
Retrospective Studies
Severity of Illness Index
Spinal cord
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Summary:Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (⩾50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458516685416