Effect of a selective SGLT2 inhibitor, luseogliflozin, on circadian rhythm of sympathetic nervous function and locomotor activities in metabolic syndrome rats

• Published in: Clinical and experimental pharmacology & physiology 2017-04, Vol.44 (4), p.522-525
• Main Authors: Rahman, Asadur, Fujisawa, Yoshihide, Nakano, Daisuke, Hitomi, Hirofumi, Nishiyama, Akira
• Format: Article
• Language: English
• Subjects: Animals; Circadian rhythm; Circadian Rhythm - drug effects; Locomotion - drug effects; Male; Metabolic syndrome; Metabolic Syndrome - physiopathology; Rats; Rodents; Sodium-Glucose Transporter 2 - antagonists & inhibitors; Sorbitol - analogs & derivatives; Sorbitol - pharmacology; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - physiopathology
• ISSN: 0305-1870; 1440-1681
• DOI: 10.1111/1440-1681.12725

Summary Metabolic syndrome is often associated with disruption of circadian rhythm of systemic haemodynamics and cardiovascular disease. Experiments were conducted to investigate the effects of luseogliflozin, a selective SGLT2 inhibitor, on circadian rhythm of sympathetic nervous function and locomotor activity (LA) in metabolic syndrome rats. The difference in the low frequency component of systolic blood pressure between the dark and light period significantly increased in the luseogliflozin‐treated SHRcp. LA also increased in the dark period compared with the light period following luseogliflozin treatment. These data suggest that circadian rhythm of sympathetic nervous function and LA is improved by luseogliflozin in metabolic syndrome rats, which may contribute to SGLT2 inhibitor‐induced improvement of cardiovascular outcomes.