Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes

Highlights • There are minor clinical features implying different genotypes for childhood GPP alone patients. • Epigenetic changes of IL36RN gene may play a role in those without mutation. • Genetic diagnosis may provide prognosis for pediatric GPP alone patients. • Most childhood GPP with both geno...

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Bibliographic Details
Published in:Journal of dermatological science 2017-03, Vol.85 (3), p.235-240
Main Authors: Wang, Yirong, Cheng, Ruhong, Lu, Zhiyong, Guo, Yifeng, Yan, Ming, Liang, Jianying, Huang, Peichen, Li, Ming, Yao, Zhirong
Format: Article
Language:English
Subjects:
Acitretin
Acitretin - therapeutic use
Adolescent
Asian Continental Ancestry Group - genetics
Child
Child, Preschool
Children
Dermatology
Epigenesis, Genetic
Female
Generalized pustular psoriasis
Genetic Predisposition to Disease
Genotype
Heterozygote
Homozygote
Humans
IL36RN gene mutation
Interleukins - genetics
Keratolytic Agents - therapeutic use
Male
Mutation
Prospective Studies
Psoriasis - drug therapy
Psoriasis - genetics
Psoriasis - pathology
Recurrence
Retrospective Studies
Suppuration - drug therapy
Suppuration - genetics
Suppuration - pathology
Withholding Treatment
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Summary:Highlights • There are minor clinical features implying different genotypes for childhood GPP alone patients. • Epigenetic changes of IL36RN gene may play a role in those without mutation. • Genetic diagnosis may provide prognosis for pediatric GPP alone patients. • Most childhood GPP with both genotypes respond well to low-dose acitretin treatment.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.11.008