Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature

Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1...

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Bibliographic Details
Published in:Clinical rheumatology 2017-03, Vol.36 (3), p.583-590
Main Authors: Giuggioli, Dilia, Colaci, M., Cassone, G., Fallahi, P., Lumetti, F., Spinella, A., Campomori, F., Manfredi, A., Manzini, C. U., Antonelli, A., Ferri, C.
Format: Article
Language:English
Subjects:
Adult
Aged
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Parathyroid Hormone - blood
Rheumatology
Scleroderma, Systemic - blood
Scleroderma, Systemic - complications
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - diagnosis
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Summary:Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency ( < 20 ng/ml), with very low vitamin D levels (
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-016-3535-z