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Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature
Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1...
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| Published in: | Clinical rheumatology 2017-03, Vol.36 (3), p.583-590 |
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| container_end_page | 590 |
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| container_title | Clinical rheumatology |
| container_volume | 36 |
| creator | Giuggioli, Dilia Colaci, M. Cassone, G. Fallahi, P. Lumetti, F. Spinella, A. Campomori, F. Manfredi, A. Manzini, C. U. Antonelli, A. Ferri, C. |
| description | Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (
<
20 ng/ml), with very low vitamin D levels ( |
| doi_str_mv | 10.1007/s10067-016-3535-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1857370958</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1857370958</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-3992fa65473199098378d99ee066de9016c7c64253bfd1798e8d8edcc077f59e3</originalsourceid><addsrcrecordid>eNp1kctOHDEQRa2IKAwkH5BNZIlNNiZ22912sUNDeEhILEjWlnFXJ0b9mNjuQcPX49EQhJDY2CXdU-W6voR8FfxYcK5_pHI2mnHRMFnLmj1-IAuhpGIACvbIgmvNmRRg9slBSvec88qA-ET2K8M1141akHCLcR5oVbObS7oO2Q1hpGe0xzX2iZY6bVLGIXiafI9xSiGdUDe6flMqOnVUKE5XLgcccypCSyOuAz5spfwXaR8yRpfniJ_Jx871Cb8834fk9_nPX8tLdn1zcbU8vWZe6iozCVB1rqmVLosDByO1aQEQedO0CMWr175RVS3vulZoMGhag633xWxXA8pD8n03dxWnfzOmbIeQPPa9G3GakxWm1lJzqE1Bj96g99Mci7ktpYWqwCgolNhRvthPETu7imFwcWMFt9sc7C4HW3az2xzsY-n59jx5vhuwfen4__EFqHZAKtL4B-Orp9-d-gTWcJHM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1871429849</pqid></control><display><type>article</type><title>Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature</title><source>Springer Nature</source><creator>Giuggioli, Dilia ; Colaci, M. ; Cassone, G. ; Fallahi, P. ; Lumetti, F. ; Spinella, A. ; Campomori, F. ; Manfredi, A. ; Manzini, C. U. ; Antonelli, A. ; Ferri, C.</creator><creatorcontrib>Giuggioli, Dilia ; Colaci, M. ; Cassone, G. ; Fallahi, P. ; Lumetti, F. ; Spinella, A. ; Campomori, F. ; Manfredi, A. ; Manzini, C. U. ; Antonelli, A. ; Ferri, C.</creatorcontrib><description>Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (
<
20 ng/ml), with very low vitamin D levels (<10 ng/ml) in 40 (44%) subjects. Only 15/49 (30.6%) patients of group B reached normal levels of 25-OH-vitD (≥30 ng/ml), whereas vitamin D deficiency persisted in 12/49 (24.5%) individuals. Parathormone levels inversely correlated with 25-OH-vitD (
r
= −0.3,
p
< 0.0001). Of interest, hypovitaminosis D was statistically associated with autoimmune thyroiditis (
p
= 0.008), while calcinosis was more frequently observed in patients of group A (
p
= 0.057). Moreover, we found significantly higher percentage of serum anticentromere antibodies in group B patients with 25-OH-vitD level ≥30 ng/ml (8/15 vs. 6/34;
p
= 0.017). In literature, hypovitaminosis D is very frequent in SSc patients. An association with disease duration, calcinosis, or severity of pulmonary involvement was occasionally recognized. Hypovitaminosis D is very frequent in SSc and severe in a relevant percentage of patients; furthermore, less than one third of supplemented subjects reached normal levels of 25-OH-vitD. The evaluation of 25-OH-vitD levels should be included in the routine clinical work-up of SSc. The above findings expand previous observations and may stimulate further investigations.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-016-3535-z</identifier><identifier>PMID: 28070764</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Aged ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Parathyroid Hormone - blood ; Rheumatology ; Scleroderma, Systemic - blood ; Scleroderma, Systemic - complications ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - diagnosis</subject><ispartof>Clinical rheumatology, 2017-03, Vol.36 (3), p.583-590</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2017</rights><rights>Clinical Rheumatology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-3992fa65473199098378d99ee066de9016c7c64253bfd1798e8d8edcc077f59e3</citedby><cites>FETCH-LOGICAL-c372t-3992fa65473199098378d99ee066de9016c7c64253bfd1798e8d8edcc077f59e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28070764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giuggioli, Dilia</creatorcontrib><creatorcontrib>Colaci, M.</creatorcontrib><creatorcontrib>Cassone, G.</creatorcontrib><creatorcontrib>Fallahi, P.</creatorcontrib><creatorcontrib>Lumetti, F.</creatorcontrib><creatorcontrib>Spinella, A.</creatorcontrib><creatorcontrib>Campomori, F.</creatorcontrib><creatorcontrib>Manfredi, A.</creatorcontrib><creatorcontrib>Manzini, C. U.</creatorcontrib><creatorcontrib>Antonelli, A.</creatorcontrib><creatorcontrib>Ferri, C.</creatorcontrib><title>Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (
<
20 ng/ml), with very low vitamin D levels (<10 ng/ml) in 40 (44%) subjects. Only 15/49 (30.6%) patients of group B reached normal levels of 25-OH-vitD (≥30 ng/ml), whereas vitamin D deficiency persisted in 12/49 (24.5%) individuals. Parathormone levels inversely correlated with 25-OH-vitD (
r
= −0.3,
p
< 0.0001). Of interest, hypovitaminosis D was statistically associated with autoimmune thyroiditis (
p
= 0.008), while calcinosis was more frequently observed in patients of group A (
p
= 0.057). Moreover, we found significantly higher percentage of serum anticentromere antibodies in group B patients with 25-OH-vitD level ≥30 ng/ml (8/15 vs. 6/34;
p
= 0.017). In literature, hypovitaminosis D is very frequent in SSc patients. An association with disease duration, calcinosis, or severity of pulmonary involvement was occasionally recognized. Hypovitaminosis D is very frequent in SSc and severe in a relevant percentage of patients; furthermore, less than one third of supplemented subjects reached normal levels of 25-OH-vitD. The evaluation of 25-OH-vitD levels should be included in the routine clinical work-up of SSc. The above findings expand previous observations and may stimulate further investigations.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Parathyroid Hormone - blood</subject><subject>Rheumatology</subject><subject>Scleroderma, Systemic - blood</subject><subject>Scleroderma, Systemic - complications</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - diagnosis</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kctOHDEQRa2IKAwkH5BNZIlNNiZ22912sUNDeEhILEjWlnFXJ0b9mNjuQcPX49EQhJDY2CXdU-W6voR8FfxYcK5_pHI2mnHRMFnLmj1-IAuhpGIACvbIgmvNmRRg9slBSvec88qA-ET2K8M1141akHCLcR5oVbObS7oO2Q1hpGe0xzX2iZY6bVLGIXiafI9xSiGdUDe6flMqOnVUKE5XLgcccypCSyOuAz5spfwXaR8yRpfniJ_Jx871Cb8834fk9_nPX8tLdn1zcbU8vWZe6iozCVB1rqmVLosDByO1aQEQedO0CMWr175RVS3vulZoMGhag633xWxXA8pD8n03dxWnfzOmbIeQPPa9G3GakxWm1lJzqE1Bj96g99Mci7ktpYWqwCgolNhRvthPETu7imFwcWMFt9sc7C4HW3az2xzsY-n59jx5vhuwfen4__EFqHZAKtL4B-Orp9-d-gTWcJHM</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Giuggioli, Dilia</creator><creator>Colaci, M.</creator><creator>Cassone, G.</creator><creator>Fallahi, P.</creator><creator>Lumetti, F.</creator><creator>Spinella, A.</creator><creator>Campomori, F.</creator><creator>Manfredi, A.</creator><creator>Manzini, C. U.</creator><creator>Antonelli, A.</creator><creator>Ferri, C.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature</title><author>Giuggioli, Dilia ; Colaci, M. ; Cassone, G. ; Fallahi, P. ; Lumetti, F. ; Spinella, A. ; Campomori, F. ; Manfredi, A. ; Manzini, C. U. ; Antonelli, A. ; Ferri, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-3992fa65473199098378d99ee066de9016c7c64253bfd1798e8d8edcc077f59e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Parathyroid Hormone - blood</topic><topic>Rheumatology</topic><topic>Scleroderma, Systemic - blood</topic><topic>Scleroderma, Systemic - complications</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giuggioli, Dilia</creatorcontrib><creatorcontrib>Colaci, M.</creatorcontrib><creatorcontrib>Cassone, G.</creatorcontrib><creatorcontrib>Fallahi, P.</creatorcontrib><creatorcontrib>Lumetti, F.</creatorcontrib><creatorcontrib>Spinella, A.</creatorcontrib><creatorcontrib>Campomori, F.</creatorcontrib><creatorcontrib>Manfredi, A.</creatorcontrib><creatorcontrib>Manzini, C. U.</creatorcontrib><creatorcontrib>Antonelli, A.</creatorcontrib><creatorcontrib>Ferri, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giuggioli, Dilia</au><au>Colaci, M.</au><au>Cassone, G.</au><au>Fallahi, P.</au><au>Lumetti, F.</au><au>Spinella, A.</au><au>Campomori, F.</au><au>Manfredi, A.</au><au>Manzini, C. U.</au><au>Antonelli, A.</au><au>Ferri, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>36</volume><issue>3</issue><spage>583</spage><epage>590</epage><pages>583-590</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease’s features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (
<
20 ng/ml), with very low vitamin D levels (<10 ng/ml) in 40 (44%) subjects. Only 15/49 (30.6%) patients of group B reached normal levels of 25-OH-vitD (≥30 ng/ml), whereas vitamin D deficiency persisted in 12/49 (24.5%) individuals. Parathormone levels inversely correlated with 25-OH-vitD (
r
= −0.3,
p
< 0.0001). Of interest, hypovitaminosis D was statistically associated with autoimmune thyroiditis (
p
= 0.008), while calcinosis was more frequently observed in patients of group A (
p
= 0.057). Moreover, we found significantly higher percentage of serum anticentromere antibodies in group B patients with 25-OH-vitD level ≥30 ng/ml (8/15 vs. 6/34;
p
= 0.017). In literature, hypovitaminosis D is very frequent in SSc patients. An association with disease duration, calcinosis, or severity of pulmonary involvement was occasionally recognized. Hypovitaminosis D is very frequent in SSc and severe in a relevant percentage of patients; furthermore, less than one third of supplemented subjects reached normal levels of 25-OH-vitD. The evaluation of 25-OH-vitD levels should be included in the routine clinical work-up of SSc. The above findings expand previous observations and may stimulate further investigations.</abstract><cop>London</cop><pub>Springer London</pub><pmid>28070764</pmid><doi>10.1007/s10067-016-3535-z</doi><tpages>8</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Adult Aged Female Humans Male Medicine Medicine & Public Health Middle Aged Original Article Parathyroid Hormone - blood Rheumatology Scleroderma, Systemic - blood Scleroderma, Systemic - complications Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - diagnosis |
| title | Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature |
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