Sleep influences the immune response and the rejection process alters sleep pattern: evidence from a skin allograft model in mice

Highlights • Sleep loss impairs the immune response. • Sleep promotes the development of the skin allograft rejection immune response. • Sleep loss impairs allograft rejection likely by reducing CD4/CD8 T cells, MHC II, IL-2 and sIL-2R. • Rejection process changed the normal sleep pattern in transpl...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.274-288
Main Authors: Silva Ruiz, Francieli, Levy Andersen, Monica, Guindalini, Camila, Pires Araujo, Leandro, Daniel Lopes, José, Tufik, Sergio
Format: Article
Language:English
Subjects:
Allergy and Immunology
Allograft
Allografts
Animals
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cytokines
Gene expression
Graft Rejection - complications
Graft Rejection - immunology
Graft Rejection - physiopathology
Immune system
Male
Mice
Psychiatry
Skin Transplantation
Sleep
Sleep - physiology
Sleep deprivation
Sleep Wake Disorders - etiology
Sleep Wake Disorders - immunology
Sleep Wake Disorders - physiopathology
T cells
Transplant
Transplantation
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Summary:Highlights • Sleep loss impairs the immune response. • Sleep promotes the development of the skin allograft rejection immune response. • Sleep loss impairs allograft rejection likely by reducing CD4/CD8 T cells, MHC II, IL-2 and sIL-2R. • Rejection process changed the normal sleep pattern in transplanted mice.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.12.027