Do MicroRNAs have a key epigenetic role in osteoarthritis and in mechanotransduction?

Osteoarthritis (OA) is the most common degenerative disease affecting joint tissues. The pathogenesis of OA is complex and poorly understood, as well as the multiple factors contributing to its development and progression. Accumulating evidence has suggested that microRNAs (miRNAs) play an important...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2017-05, Vol.35 (3), p.518-526
Main Authors: De Palma, Anna, Cheleschi, Sara, Pascarelli, Nicola Antonio, Tenti, Sara, Galeazzi, Mauro, Fioravanti, Antonella
Format: Article
Language:English
Subjects:
Cartilage - metabolism
Cartilage - pathology
Epigenesis, Genetic
Gene Expression Regulation
Genetic Markers
Genetic Therapy - methods
Humans
Male
Mechanotransduction, Cellular - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Osteoarthritis - genetics
Osteoarthritis - metabolism
Osteoarthritis - pathology
Osteoarthritis - therapy
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Summary:Osteoarthritis (OA) is the most common degenerative disease affecting joint tissues. The pathogenesis of OA is complex and poorly understood, as well as the multiple factors contributing to its development and progression. Accumulating evidence has suggested that microRNAs (miRNAs) play an important role as regulators of cartilage biology and in the pathogenesis of OA. It has been demonstrated that mechanical loading, important for the regulation of cartilage metabolism, affects miRNAs expression. Furthermore, miRNAs present in human plasma and in synovial fluid could represent promising biological markers for OA. Herein, we have reviewed the current state of research on miRNAs in cartilage homeostasis and OA pathogenesis and their potential clinical applications.
ISSN:0392-856X