Study of π-A curves for mixed monolayers of cyclosporin and poly(DL-lactic acid-co-glycolic acid) spread at the air/water interface

Mixed monolayers of CyA and poly(dl-lactic acid-co-glycolic acid) spread at the air/water interface were studied by measuring surface pressure (pi) as a function of the area per residue (A). The pi-A curves suggest that the components are miscible below surface pressures of 10 mN/m. Also, the diagra...

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Bibliographic Details
Published in:Journal of colloid and interface science 1997, Vol.185 (1), p.77-83
Main Authors: VILA ROMEU, N, MINONES, J, CONDE, O, IRIBARNEGARAY, E, CASAS, M
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Exact sciences and technology
Immunomodulators
Medical sciences
Organic polymers
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
Surface properties
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Summary:Mixed monolayers of CyA and poly(dl-lactic acid-co-glycolic acid) spread at the air/water interface were studied by measuring surface pressure (pi) as a function of the area per residue (A). The pi-A curves suggest that the components are miscible below surface pressures of 10 mN/m. Also, the diagrams obtained by plotting the mean area per residue as a function of molar fraction show positive deviations from ideal, which indicate the existence of interactions between both components in the mixed films. The nature of these interactions was influenced by the pH and temperature of the subphase; however, it was not dependent on the molecular size of the polymer. Above pi = 10 mN/m mixed monolayers showed immiscible behavior with no interactions between their components. This was manifested by the obedience to the mean area additivity rule and the same value of collapse pressure present for all mixed monolayers studied.
ISSN:0021-9797
1095-7103
DOI:10.1006/jcis.1996.4523