New Bis(Indole) Alkaloids of the Topsentin Class from the Sponge Spongosorites genitrix

Four bis(indole) alkaloids of the topsentin class, including two new brominated compounds (1 and 2), have been isolated from the sponge Spongosorites genitrix collected from Jaeju Island, Korea. The structures of the novel compounds were determined by spectroscopic methods. These compounds exhibited...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-04, Vol.62 (4), p.647-649
Main Authors: Shin, Jongheon, Seo, Youngwan, Cho, Ki Woong, Rho, Jung-Rae, Sim, Chung J
Format: Article
Language:English
Subjects:
bis(indole) alkaloids
Marine
Spongosorites genitrix
topsentins
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Summary:Four bis(indole) alkaloids of the topsentin class, including two new brominated compounds (1 and 2), have been isolated from the sponge Spongosorites genitrix collected from Jaeju Island, Korea. The structures of the novel compounds were determined by spectroscopic methods. These compounds exhibited moderate cytotoxicity against a human leukemia cell-line (K-562).
ISSN:0163-3864
1520-6025
DOI:10.1021/np980507b