Convergent automated parallel synthesis

As combinatorial chemistry approaches its second decade of widespread use, the developmental pathways that could shape its future are becoming increasingly apparent. Progress down one of these pathways is driven by the desire to make and test more complex molecules containing intricate ring systems,...

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Bibliographic Details
Published in:Drug Discovery Today 1999-08, Vol.4 (8), p.377-383
Main Authors: Powers, David G., Coffen, David L.
Format: Article
Language:English
Subjects:
Automated
Biological and medical sciences
Combinatorial
Convergent
General pharmacology
Medical sciences
Parallel processing
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:As combinatorial chemistry approaches its second decade of widespread use, the developmental pathways that could shape its future are becoming increasingly apparent. Progress down one of these pathways is driven by the desire to make and test more complex molecules containing intricate ring systems, stereochemical features and elaborate presentations of functional groups – molecules that resemble real drugs and natural products. The realization of this desire requires the recruitment of more of the methods and principles of complex molecule synthesis into combinatorial chemistry, thereby creating hybrid operating systems such as ‘convergent automated parallel synthesis’.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(99)01364-1