The Stripe Sign: Correlation of Radionuclide Ventilation and Perfusion With He-3 Magnetic Resonance Lung Imaging

• Published in: Clinical nuclear medicine 1999-10, Vol.24 (10), p.747-747
• Main Authors: TEATES, C DAVID, BROOKEMAN, JAMES R, DANIEL, THOMAS M, TRUWIT, JONATHON D, PAREKH, JAYASHREE S, MUGLER, JOHN P, DE LANGE, EDUARD E
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Radionuclide investigations; Respiratory system
• ISSN: 0363-9762; 1536-0229
• DOI: 10.1097/00003072-199910000-00003

PURPOSEThe aim of this study was to correlate regional ventilation and perfusion images and perfusion SPECT with images made using a newly developed magnetic resonance ventilation (MRV) method. MATERIALS AND METHODSThe investigation included a single patient with chronic obstructive pulmonary disease and a healthy control participant. Ventilation and perfusion images using Xe-133 and Tc-99m MAA, including perfusion SPECT, were compared with single-breath MRV with hyperpolarized He-3. RESULTSVentilation and perfusion defects correspond to areas of poor ventilation on MRV. High-resolution MRV images show preservation of bronchi and acinus units in areas of the “stripe sign” on the V/Q study. CONCLUSIONSMRV imaging confirms that the stripe sign seen on nuclear perfusion imaging correlates with subsegmental preserved lung. MRV imaging has the potential for high-resolution innovative studies of subsegmental lung function, using either He-3 or Xe-129 hyperpolarized gases.