Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement

SUMMARY  Studies with the serotonin uptake inhibitors zimeldine and alaproclate show biphasic effects on the sleep/wake axis in rats and cats. Zimeldine induced an initial waking response succeeded by a small SWS‐2 increase in rats. The waking increase was not blocked by the 5‐HT2 antagonist ritanse...

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Bibliographic Details
Published in:Journal of sleep research 1992-09, Vol.1 (3), p.157-162
Main Authors: URSIN, R., BJORVATN, B., SOMMERFELT, L., NECKELMANN, D., BJØRKUM, A. A.
Format: Article
Language:English
Subjects:
5‐HT mechanisms
alaproclate
ritanserin
slow‐wave sleep
zimeldine
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Summary:SUMMARY  Studies with the serotonin uptake inhibitors zimeldine and alaproclate show biphasic effects on the sleep/wake axis in rats and cats. Zimeldine induced an initial waking response succeeded by a small SWS‐2 increase in rats. The waking increase was not blocked by the 5‐HT2 antagonist ritanserin nor by the putative 5‐HT1A antagonist (‐)‐alprenolol. In cats, zimeldine induced initial behavioural changes which were succeeded by a large SWS‐2 increase. Alaproclate gave similar initial responses as zimeldine in both species, and was succeeded by a moderate sleep increase in cats but not in rats. The complex sleep/wake effects following the serotonin uptake inhibitors may result from simultaneous induction of incompatible serotonergic effects.
ISSN:0962-1105
1365-2869
DOI:10.1111/j.1365-2869.1992.tb00031.x