Copper(II) Complexes of Opiate-like Food Peptides

The α-casein peptide fragment (90−96) Arg-Tyr-Leu-Gly-Tyr-Leu-Glu, one of the exorphins called “food hormones”, is an efficient ligand for CuII ions. Potentiometric and spectroscopic studies on aqueous solutions indicate that, depending on the pH range, complex species with different coordination mo...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1998-01, Vol.46 (1), p.115-118
Main Authors: Lodyga-Chruscinska, Elzbieta, Micera, Giovanni, Szajdzinska-Piêtek, Ewa, Sanna, Daniele
Format: Article
Language:English
Subjects:
ALPHA-CASEIN
AMINO ACID SEQUENCES
Aminoacids, peptides. Hormones. Neuropeptides
Analytical, structural and metabolic biochemistry
BINDING
Biological and medical sciences
CASEIN
CASEINA
CASEINE
CATION
CATIONES
CATIONS
CHEMICAL COMPOSITION
COBRE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
COPPER
CUIVRE
ESPECTROMETRIA
EXORPHINS
Fundamental and applied biological sciences. Psychology
INTERACTIONS
LIGAND
LIGANDOS
LIGANDS
METAL
METALES
METALS
PROTEIN-METAL ION INTERACTIONS
Proteins
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
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Description
Summary:The α-casein peptide fragment (90−96) Arg-Tyr-Leu-Gly-Tyr-Leu-Glu, one of the exorphins called “food hormones”, is an efficient ligand for CuII ions. Potentiometric and spectroscopic studies on aqueous solutions indicate that, depending on the pH range, complex species with different coordination modes (involving the amino and the deprotonated amide groups) are formed. The phenolate side chain of the Tyr residue is not involved in the metal coordination. Keywords: Arg-Tyr-Leu-Gly-Tyr-Leu-Glu; α-casein; exorphins; copper(II) complexes
ISSN:0021-8561
1520-5118
DOI:10.1021/jf970586h