Diagnosis and prediction of recurrence and progression in superficial bladder cancers with DNA image cytometry and urinary cytology

• Published in: BJU international 2000-01, Vol.85 (1), p.32-34
• Main Authors: Desgrippes, A., Izadifar, V., Assailly, J., Fontaine, E., Beurton, D.
• Format: Article
• Language: English
• Subjects: DNA ploidy; progression; recurrence; superficial bladder cancer; urinary cytology
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1046/j.1464-410x.2000.00361.x

ObjectiveTo investigate the roles of urinary cytology and image cytometric analysis of nuclear DNA ploidy pattern in the diagnosis and prediction of recurrence and/or progression of superficial bladder cancers. Patients and methodsAliquots of catheterized urine from 92 patients with primary (23) or previous (69) superficial bladder cancers were assessed using urine cytology and image‐analysis cytometry independently. ResultsOf the 23 primary superficial transitional cell carcinomas (TCCs), 11 (48%) were detected by urinary cytology while 12 (52%) were detected by image‐analysis cytometry (P > 0.05) and 13 (57%) were revealed by combined cytology and cytometry. Of 42 recurrent superficial TCCs, 29 (69%) were detected by urinary cytology, whilst 19 (45%) were diagnosed by cytometry (P  0.05). The positivity of DNA image cytometry had no significant association (P > 0.05) with tumour recurrence and/or progression. ConclusionsDNA image cytometry can provide a limited but not significant advantage over urinary cytology in the detection of primary superficial TCCs, but it does not seem to be indicated for the prediction of tumour recurrence and/or progression.