Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin

The inhibition of angiogenesis in vivo as a result of the inhibition of Ets‐1 transcription factor expression by the ets‐1 phosphorothioate antisense oligodeoxynucleotide 5′‐AGATCGACGGCCGCCTTCAT‐3′ has been proven by experiments with chicken embryos. Thus, participation of the Ets‐1 transcription fa...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 1999-11, Vol.38 (21), p.3228-3231
Main Authors: Wernert, Nicolas, Stanjek, Antje, Kiriakidis, Serafim, Hügel, Anja, Jha, Hem Chandra, Mazitschek, Ralph, Giannis, Athanassios
Format: Article
Language:English
Subjects:
Angiogenesis
Antibiotics
Antisense agents
Biocompatibility
Biomedical materials
Blood vessels
Embryos
In vivo testing
In vivo tests
Inhibition
Inhibitors
Surgical implants
Tumor therapy
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Summary:The inhibition of angiogenesis in vivo as a result of the inhibition of Ets‐1 transcription factor expression by the ets‐1 phosphorothioate antisense oligodeoxynucleotide 5′‐AGATCGACGGCCGCCTTCAT‐3′ has been proven by experiments with chicken embryos. Thus, participation of the Ets‐1 transcription factor in the formation of new blood vessels in vivo has been demonstrated. Furthermore, it is shown that the angiostatic effect of the fungal metabolite and angiogenesis inhibitor fumagillin is mainly a result of its ability to inhibit Ets‐1 expression.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19991102)38:21<3228::AID-ANIE3228>3.0.CO;2-8