New Polyfunctional Magnesium Reagents for Organic Synthesis

The iodine‐magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper‐catalyzed reactions such as allylation or 1,4‐addition. U...

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Bibliographic Details
Published in:Chemistry : a European journal 2000-03, Vol.6 (5), p.767-770
Main Authors: Rottländer, Mario, Boymond, Laure, Bérillon, Laurent, Leprêtre, Anne, Varchi, Greta, Avolio, Salvatore, Laaziri, Hamid, Quéguiner, Guy, Ricci, Alfredo, Cahiez, Gérard, Knochel, Paul
Format: Article
Language:English
Subjects:
catalysis
copper
cyclizations
heterocycles
magnesium
solid-phase synthesis
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Summary:The iodine‐magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper‐catalyzed reactions such as allylation or 1,4‐addition. Using this halogen‐metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase. La synthèse d'organomagnésiens polyfonctionalisés aryliques, hétéroaryliques et vinyliques a été réalisée par échange iode‐magnésium à basse température. Leur réactivité vis à vis de différents électrophyles (allylation, addition 1–;4 ‥) a été étudiée ainsi que leur application en phase solide.
ISSN:0947-6539
1521-3765
DOI:10.1002/(SICI)1521-3765(20000303)6:5<767::AID-CHEM767>3.0.CO;2-X