The antihypertensive effects of doxazosin on the arterial system: changes in peripheral vascular resistance and wall tension

• Published in: European journal of internal medicine 2000-06, Vol.11 (3), p.140-144
• Main Authors: Karter, Yesari, Aran, Sinan, Seyahi, Nurhan, Tunçkale, Aydın, Yaldıran, Adnan, Sipahioǧlu, Fikret, Öztürk, Esin
• Format: Article
• Language: English
• Subjects: Doxazosin; Hypertension; Peripheral resistance; Wall tension
• ISSN: 0953-6205; 1879-0828
• DOI: 10.1016/S0953-6205(00)00077-7

Background: Hypertension is characterized by structural and functional abnormalities that affect the entire cardiovascular system, including the large arteries. The antihypertensive efficacy of doxazosin, a selective α 1 antagonist, and its effects on the arterial system were investigated. Method: In our double-blind, randomized, placebo-controlled study including 30 hypertensive patients (doxazosin group: nine males, 11 females; mean age 45±12 years; placebo group: four males, six females; mean age 47±9 years), the systolic, diastolic and mean blood pressure (BP), heart rate, diameter and area of the brachial artery, peak systolic velocity, end-diastolic velocity, pulsatility index (PI), resistance index (RI), S/ D (systolic velocity/diastolic velocity), flow volume, local resistance, and wall tension were recorded before and 4 h after the administration of 2 mg doxazosin or placebo. The two groups were statistically compared. Results: In the doxazosin group, systolic, diastolic and mean pressures decreased significantly ( P