Synthesis of Macrocyclic Cage Compounds by Diamine−Dihalide One-Step Coupling Reaction

Macropolycyclic cage compounds were synthesized by a direct reaction between diamines and bis(bromomethyl) compounds. The procedure for constructing the polycyclic cage structure is simple and straightforward. The macropolycyclic compounds obtainable from this cyclization procedure are three-dimensi...

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Bibliographic Details
Published in:Journal of organic chemistry 2000-06, Vol.65 (12), p.3708-3715
Main Authors: Kon, Noriyoshi, Takemura, Hiroyuki, Otsuka, Kazuhiro, Tanoue, Kiyoshi, Nakashima, Sachiko, Yasutake, Mikio, Tani, Keita, Kimoto, Junko, Shinmyozu, Teruo, Inazu, Takahiko
Format: Article
Language:English
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Summary:Macropolycyclic cage compounds were synthesized by a direct reaction between diamines and bis(bromomethyl) compounds. The procedure for constructing the polycyclic cage structure is simple and straightforward. The macropolycyclic compounds obtainable from this cyclization procedure are three-dimensional cage compounds, and any other isomers were not obtained except for two examples. Benzene, pyridine, and aliphatic units could be introduced into the cage structure. The macrocycles that have strong cation affinity were obtained as their potassium complexes.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo991911y