Different effects of conjugated linoleic acid isomers on lipoprotein lipase activity in 3T3-L1 adipocytes

Conjugated linoleic acids (CLAs) are the positional and geometric isomers of linoleic acid. In the present study the effects of cis-9, trans-11 CLA (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA ) on intracellular and heparin-releasable (HR-) lipoprotein lipase (LPL) activity in 3T3-L1 adipocyte...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2001-03, Vol.12 (3), p.183-189
Main Authors: Lin, Yuguang, Kreeft, Arja, Schuurbiers, Johan A.E, Draijer, Richard
Format: Article
Language:English
Subjects:
3T3 L1 adipocytes
Biological and medical sciences
Conjugated linoleic acid
Fatty acids
Fundamental and applied biological sciences. Psychology
Lipoprotein lipase
Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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Summary:Conjugated linoleic acids (CLAs) are the positional and geometric isomers of linoleic acid. In the present study the effects of cis-9, trans-11 CLA (c9,t11 CLA) and trans-10, cis-12 CLA (t10,c12 CLA ) on intracellular and heparin-releasable (HR-) lipoprotein lipase (LPL) activity in 3T3-L1 adipocytes were investigated. Cells were exposed to the two CLA isomers and linoleic acid, which were bound to bovine serum albumin (BSA). In the adipocytes insulin up-regulated and tumor necrosis factor alpha (TNFα) down-regulated HR-LPL activity, which corresponds with the findings in vivo. The experimental fatty acids at low concentrations (
ISSN:0955-2863
1873-4847
DOI:10.1016/S0955-2863(00)00155-8