In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography

Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: eluc...

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Bibliographic Details
Published in:Drug Discovery Today 2001-03, Vol.6 (6), p.293-302
Main Authors: Aboagye, Eric O, Price, Patricia M, Jones, Terry
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Imaging
Medical sciences
PET
Pharmacodynamics
Pharmacokinetics
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Receptor occupancy
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Summary:Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology, evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(01)01684-1