Exploiting human genetic variation in drug discovery and development

‘The right drug for the right patient at the right time’ Is this a realistic goal for today's pharmaceutical industry and tomorrow's medical practitioner? Or merely an over-simplistic refrain that can only ever be an unfulfilled dream? Here we discuss the reality behind the dream and illus...

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Bibliographic Details
Published in:Drug Discovery Today 2001-02, Vol.6 (4), p.198-205
Main Author: Jazwinska, Elizabeth C
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
genetic variation
human genome
Medical sciences
pharmacogenetics
Pharmacology. Drug treatments
single nucleotide polymorphism
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Summary:‘The right drug for the right patient at the right time’ Is this a realistic goal for today's pharmaceutical industry and tomorrow's medical practitioner? Or merely an over-simplistic refrain that can only ever be an unfulfilled dream? Here we discuss the reality behind the dream and illustrate how the analysis of genetic variation is a complex science that has the capacity to make significant contributions to drug discovery and development strategies. An understanding of the impact of human variation must be a central consideration in the future practice of pharmaceutical R&D.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(00)01642-1