Physiology of Receptor-Mediated Lymphocyte Apoptosis

F. Lang , I. Szabo , A. Lepple-Wienhues , D. Siemen and E. Gulbins F. Lang, I. Szabo, A. Lepple-Wienhues, D. Siemen, and E. Gulbins are in the Department for Physiology of the University of Tübingen, Gmelinstrasse 5, D-72076 Tübingen, Germany. Apoptosis (programmed cell death), a physiological mecha...

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Bibliographic Details
Published in:News in physiological sciences 1999-10, Vol.14 (5), p.194-200
Main Authors: Lang, F, Szabo, I, Lepple-Wienhues, A, Siemen, D, Gulbins, E
Format: Article
Language:English
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Summary:F. Lang , I. Szabo , A. Lepple-Wienhues , D. Siemen and E. Gulbins F. Lang, I. Szabo, A. Lepple-Wienhues, D. Siemen, and E. Gulbins are in the Department for Physiology of the University of Tübingen, Gmelinstrasse 5, D-72076 Tübingen, Germany. Apoptosis (programmed cell death), a physiological mechanism eliminating abundant and potentially harmful cells, is triggered by a variety of stimuli including activation of distinct receptors. The machinery mediating CD95 receptor-induced apoptosis includes caspases, ceramide, kinases, Ras and Rac, formation of O 2 – , mitochondrial proteins, inhibition of K + channels, activation of Cl – channels, and osmolyte release.
ISSN:1548-9213
0886-1714
1548-9221
DOI:10.1152/physiologyonline.1999.14.5.194