Plasma homocysteine concentrations of Indonesian children with inadequate and adequate vitamin B-6 status

• Published in: Nutrition research (New York, N.Y.) N.Y.), 2001-07, Vol.21 (7), p.961-966
• Main Authors: Giraud, David W., Driskell, Judy A., Setiawan, Budi
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Children; Indonesians; Medical sciences; Metabolic diseases; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...); Plasma homocysteine; Tropical medicine; Vitamin B-6 status
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/S0271-5317(01)00309-8

The objective of the study was to determine the usefulness of utilizing plasma homocysteine concentrations as an indicator of vitamin B-6 status in subjects with inadequate and adequate status as demonstrated by currently accepted indicators. Plasma homocysteine concentrations of 77 third-grade Indonesian children (aged 8–9 y; boys and girls) were measured. About a quarter of these subjects had inadequate vitamin B-6 status as indicated by their plasma pyridoxal-5′-phosphate concentrations, erythrocyte alanine aminotransferase activity coefficients, and reported dietary vitamin B-6 intakes. No significant differences in plasma homocysteine concentrations were observed between subject groups shown to have inadequate and adequate vitamin B-6 status using currently accepted indicators. Plasma homocysteine concentrations of the subjects were not correlated with values for other vitamin B-6 indices. Plasma homocysteine concentration was not an indicator of vitamin B-6 status in these children, as it did not differentiate between children shown otherwise to have inadequate and adequate status of the vitamin.