Plasma levels of soluble cellular adhesion molecules in patients with arterial hypertension. Correlations with plasma endothelin-1

Background: Several reports have shown that circulating, soluble cellular adhesion molecules and endothelin-1 (ET-1) are implicated in the pathophysiological events of atherosclerosis and may reflect the endothelial dysfunction characterizing this disorder. Methods: To evaluate the expression of the...

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Bibliographic Details
Published in:European journal of internal medicine 2001-07, Vol.12 (4), p.350-356
Main Authors: Parissis, John T, Venetsanou, Koula F, Mentzikof, Demetrios G, Kalantzi, Maria V, Georgopoulou, Maria V, Chrisopoulos, Nikolaos, Karas, Spilios M
Format: Article
Language:English
Subjects:
Cardiovascular risk factors
Cellular adhesion molecules
Endothelial dysfunction
Endothelin-1
Inflammation
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Summary:Background: Several reports have shown that circulating, soluble cellular adhesion molecules and endothelin-1 (ET-1) are implicated in the pathophysiological events of atherosclerosis and may reflect the endothelial dysfunction characterizing this disorder. Methods: To evaluate the expression of these factors in arterial hypertension (AH), we measured plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble P-selectin (sP-selectin), and ET-1 in 60 untreated patients with mild to moderate AH (hypercholesterolemic: n=31, normocholesterolemic: n=29) and 30 sex- and age-matched normocholesterolemic normotensive controls. Results: Hypertensive patients exhibited significantly higher levels of sICAM-1 (234±21 vs. 187±12 ng/ml, P
ISSN:0953-6205
1879-0828
DOI:10.1016/S0953-6205(01)00125-X