Adociasulfates 1−6, Inhibitors of Kinesin Motor Proteins from the Sponge Haliclona (aka Adocia) sp

Adociasulfates 1−6 (1−6) were isolated from an extract of the Palauan sponge Haliclona (aka Adocia) sp. that inhibited the transport of stabilized microtubules by the motor protein kinesin, which was immobilized on a microscope slide. The structures of adociasulfates 1−6, the relative stereochemistr...

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Bibliographic Details
Published in:Journal of organic chemistry 1999-07, Vol.64 (15), p.5565-5570
Main Authors: Blackburn, Christine L, Hopmann, Cordula, Sakowicz, Roman, Berdelis, Michael S, Goldstein, Lawrence S. B, Faulkner, D. John
Format: Article
Language:English
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Summary:Adociasulfates 1−6 (1−6) were isolated from an extract of the Palauan sponge Haliclona (aka Adocia) sp. that inhibited the transport of stabilized microtubules by the motor protein kinesin, which was immobilized on a microscope slide. The structures of adociasulfates 1−6, the relative stereochemistry of adociasulfates 1, 2, 5, and 6, and the relative stereochemistry of subunits of adociasulfates 3 and 4 were determined by interpretation of spectroscopic data. In a quantitative assay that measures ATP hydrolysis by kinesin, adociasulfates 2 and 6 were the most active.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo9824448