New Tools for Studying Vesicular-Mediated Protein Trafficking:  Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay

Structural variants of the marine sponge metabolite ilimaquinone, with comparable biological activity, have been prepared. These analogs, as well as related natural products, were screened for their effects on the Golgi apparatus through a novel, non-radioisotope-based secretion assay. The assay has...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 1997-05, Vol.62 (9), p.2823-2831
Main Authors: Radeke, Heike S, Digits, Cheryl A, Bruner, Steven D, Snapper, Marc L
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-a417t-40f955c3353da1a5415e81f5442df4b7f6d594870d6159f4610c25e5e1945b203
cites cdi_FETCH-LOGICAL-a417t-40f955c3353da1a5415e81f5442df4b7f6d594870d6159f4610c25e5e1945b203
container_end_page 2831
container_issue 9
container_start_page 2823
container_title Journal of organic chemistry
container_volume 62
creator Radeke, Heike S
Digits, Cheryl A
Bruner, Steven D
Snapper, Marc L
description Structural variants of the marine sponge metabolite ilimaquinone, with comparable biological activity, have been prepared. These analogs, as well as related natural products, were screened for their effects on the Golgi apparatus through a novel, non-radioisotope-based secretion assay. The assay has identified a variant of ilimaquinone that contains a versatile linker group yet retains the natural product's cellular activity. This functional ilimaquinone analog will be a valuable tool for studying intracellular protein trafficking.
doi_str_mv 10.1021/jo962292l
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859361884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859361884</sourcerecordid><originalsourceid>FETCH-LOGICAL-a417t-40f955c3353da1a5415e81f5442df4b7f6d594870d6159f4610c25e5e1945b203</originalsourceid><addsrcrecordid>eNpt0cFuFCEYB3BiNHatHnwBw8VED6PAADPjbdtUram1umuvhB2g0s7Clo9pnZtXX8NH80nE7KZe5MKBX_5f-P4IPaXkFSWMvr6MnWSsY8M9NKOCkUp2hN9HM0IYq2om6z30COCSlCOEeIj2KJUNlVzM0K9Te4uXMQ6AXUx4kUcz-XCBzy34fhx0qj5a43W2Bp-lmK0PeJm0c76_KuzN7x8_8WIK-VvhgHUw-OhGD6POPgYcHT4e_Fpfjz7EYPE86CFeAC4ZGp_GUH3RxkcPMceNrQ40lCHzkD3YPtkc04TnAHp6jB44PYB9srv30de3R8vD99XJp3fHh_OTSnPa5IoT1wnR17WojaZacCpsS53gnBnHV42TRnS8bYiRVHSOS0p6JqywtONixUi9j15sczcpXo8Wslp76O0w6GDjCIq2oqslbVte6Mst7VMESNapTSofTZOiRP2tRN1VUuyzXey4WlvzT-46KKDaAg_Zfr971-lKyaZuhFqeLZRknwVnH85VXfzzrdc9lDljKmuF_wz-A6FJpBM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859361884</pqid></control><display><type>article</type><title>New Tools for Studying Vesicular-Mediated Protein Trafficking:  Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read &amp; Publish Agreement 2022-2024 (Reading list)</source><creator>Radeke, Heike S ; Digits, Cheryl A ; Bruner, Steven D ; Snapper, Marc L</creator><creatorcontrib>Radeke, Heike S ; Digits, Cheryl A ; Bruner, Steven D ; Snapper, Marc L</creatorcontrib><description>Structural variants of the marine sponge metabolite ilimaquinone, with comparable biological activity, have been prepared. These analogs, as well as related natural products, were screened for their effects on the Golgi apparatus through a novel, non-radioisotope-based secretion assay. The assay has identified a variant of ilimaquinone that contains a versatile linker group yet retains the natural product's cellular activity. This functional ilimaquinone analog will be a valuable tool for studying intracellular protein trafficking.</description><identifier>ISSN: 0022-3263</identifier><identifier>EISSN: 1520-6904</identifier><identifier>DOI: 10.1021/jo962292l</identifier><identifier>PMID: 11671645</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><ispartof>Journal of organic chemistry, 1997-05, Vol.62 (9), p.2823-2831</ispartof><rights>Copyright © 1997 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a417t-40f955c3353da1a5415e81f5442df4b7f6d594870d6159f4610c25e5e1945b203</citedby><cites>FETCH-LOGICAL-a417t-40f955c3353da1a5415e81f5442df4b7f6d594870d6159f4610c25e5e1945b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11671645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radeke, Heike S</creatorcontrib><creatorcontrib>Digits, Cheryl A</creatorcontrib><creatorcontrib>Bruner, Steven D</creatorcontrib><creatorcontrib>Snapper, Marc L</creatorcontrib><title>New Tools for Studying Vesicular-Mediated Protein Trafficking:  Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay</title><title>Journal of organic chemistry</title><addtitle>J. Org. Chem</addtitle><description>Structural variants of the marine sponge metabolite ilimaquinone, with comparable biological activity, have been prepared. These analogs, as well as related natural products, were screened for their effects on the Golgi apparatus through a novel, non-radioisotope-based secretion assay. The assay has identified a variant of ilimaquinone that contains a versatile linker group yet retains the natural product's cellular activity. This functional ilimaquinone analog will be a valuable tool for studying intracellular protein trafficking.</description><issn>0022-3263</issn><issn>1520-6904</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpt0cFuFCEYB3BiNHatHnwBw8VED6PAADPjbdtUram1umuvhB2g0s7Clo9pnZtXX8NH80nE7KZe5MKBX_5f-P4IPaXkFSWMvr6MnWSsY8M9NKOCkUp2hN9HM0IYq2om6z30COCSlCOEeIj2KJUNlVzM0K9Te4uXMQ6AXUx4kUcz-XCBzy34fhx0qj5a43W2Bp-lmK0PeJm0c76_KuzN7x8_8WIK-VvhgHUw-OhGD6POPgYcHT4e_Fpfjz7EYPE86CFeAC4ZGp_GUH3RxkcPMceNrQ40lCHzkD3YPtkc04TnAHp6jB44PYB9srv30de3R8vD99XJp3fHh_OTSnPa5IoT1wnR17WojaZacCpsS53gnBnHV42TRnS8bYiRVHSOS0p6JqywtONixUi9j15sczcpXo8Wslp76O0w6GDjCIq2oqslbVte6Mst7VMESNapTSofTZOiRP2tRN1VUuyzXey4WlvzT-46KKDaAg_Zfr971-lKyaZuhFqeLZRknwVnH85VXfzzrdc9lDljKmuF_wz-A6FJpBM</recordid><startdate>19970502</startdate><enddate>19970502</enddate><creator>Radeke, Heike S</creator><creator>Digits, Cheryl A</creator><creator>Bruner, Steven D</creator><creator>Snapper, Marc L</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970502</creationdate><title>New Tools for Studying Vesicular-Mediated Protein Trafficking:  Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay</title><author>Radeke, Heike S ; Digits, Cheryl A ; Bruner, Steven D ; Snapper, Marc L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a417t-40f955c3353da1a5415e81f5442df4b7f6d594870d6159f4610c25e5e1945b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radeke, Heike S</creatorcontrib><creatorcontrib>Digits, Cheryl A</creatorcontrib><creatorcontrib>Bruner, Steven D</creatorcontrib><creatorcontrib>Snapper, Marc L</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radeke, Heike S</au><au>Digits, Cheryl A</au><au>Bruner, Steven D</au><au>Snapper, Marc L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Tools for Studying Vesicular-Mediated Protein Trafficking:  Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay</atitle><jtitle>Journal of organic chemistry</jtitle><addtitle>J. Org. Chem</addtitle><date>1997-05-02</date><risdate>1997</risdate><volume>62</volume><issue>9</issue><spage>2823</spage><epage>2831</epage><pages>2823-2831</pages><issn>0022-3263</issn><eissn>1520-6904</eissn><abstract>Structural variants of the marine sponge metabolite ilimaquinone, with comparable biological activity, have been prepared. These analogs, as well as related natural products, were screened for their effects on the Golgi apparatus through a novel, non-radioisotope-based secretion assay. The assay has identified a variant of ilimaquinone that contains a versatile linker group yet retains the natural product's cellular activity. This functional ilimaquinone analog will be a valuable tool for studying intracellular protein trafficking.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>11671645</pmid><doi>10.1021/jo962292l</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0022-3263
ispartof Journal of organic chemistry, 1997-05, Vol.62 (9), p.2823-2831
issn 0022-3263
1520-6904
language eng
recordid cdi_proquest_miscellaneous_1859361884
source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
title New Tools for Studying Vesicular-Mediated Protein Trafficking:  Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T18%3A25%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20Tools%20for%20Studying%20Vesicular-Mediated%20Protein%20Trafficking:%E2%80%89%20Synthesis%20and%20Evaluation%20of%20Ilimaquinone%20Analogs%20in%20a%20Non-Radioisotope-Based%20Antisecretory%20Assay&rft.jtitle=Journal%20of%20organic%20chemistry&rft.au=Radeke,%20Heike%20S&rft.date=1997-05-02&rft.volume=62&rft.issue=9&rft.spage=2823&rft.epage=2831&rft.pages=2823-2831&rft.issn=0022-3263&rft.eissn=1520-6904&rft_id=info:doi/10.1021/jo962292l&rft_dat=%3Cproquest_cross%3E1859361884%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a417t-40f955c3353da1a5415e81f5442df4b7f6d594870d6159f4610c25e5e1945b203%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1859361884&rft_id=info:pmid/11671645&rfr_iscdi=true