A plasmid-mediated beta-lactamase with carbapenem-hydrolyzing activity from Serratia marcescens

Serratia marcescens W-313/pSW313 was isolated from a clinical specimen that showed resistance to various beta-lactams. beta-Lactamase from this strain hydrolyzed oxyiminocephalosporins and carbapenems, but did not hydrolyze 2-carboxypenam and aztreonam. The kinetic parameters of this enzyme were sim...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 1999-03, Vol.5 (1), p.49-51
Main Authors: Matsumura, N., Yotsuji, Akira, Minami, Shinzaburo, Mitsuhashi, Susumu
Format: Article
Language:English
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Summary:Serratia marcescens W-313/pSW313 was isolated from a clinical specimen that showed resistance to various beta-lactams. beta-Lactamase from this strain hydrolyzed oxyiminocephalosporins and carbapenems, but did not hydrolyze 2-carboxypenam and aztreonam. The kinetic parameters of this enzyme were similar to those of the carbapenem-hydrolyzing beta-lactamases mediated by R-plasmid from Pseudomonas aeruginosa and S. marcescens, whose properties were previously reported.
ISSN:1341-321X
1437-7780
DOI:10.1007/s101560050008