Effect of Dopamine Agonists on Lactotroph Adenomas of the Human Pituitary

Dopamine (DA) agonists cause reduction of blood prolactin level and tumor shrinkage in most patients with lactotroph adenoma. Our aim was to investigate the cellular mechanism of tumor shrinkage by determining mitotic, MIB-1, p27, and apoptotic indices, as well as microvessel density (MVD), surface...

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Bibliographic Details
Published in:Endocrine pathology 2000, Vol.11 (4), p.341-352
Main Authors: Stefaneanu, Lucia, Kovacs, Kalman, Scheithauer, Bernd W., Kontogeorgos, George, Riehle, Darren L., Sebo, Thomas J., Murray, David, Vidal, Sergio, Tran, Ami, Buchfelder, Michael, Fahlbusch, Rudolf
Format: Article
Language:English
Subjects:
Colorectal cancer
Dopamine
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Summary:Dopamine (DA) agonists cause reduction of blood prolactin level and tumor shrinkage in most patients with lactotroph adenoma. Our aim was to investigate the cellular mechanism of tumor shrinkage by determining mitotic, MIB-1, p27, and apoptotic indices, as well as microvessel density (MVD), surface microvessel density (SMD). ploidy, and other nuclear parameters. Surgically removed lactotroph adenomas were selected from 29 patients, of whom 19 were treated with oral bromocriptine (BEC), long-acting injectable BEC (BEC-LAR), or quinagolide and 10 were untreated. In treated adenomas mitotic and MIB-1 indices were lower, whereas the apoptotic indices were not significantly higher compared to untreated adenomas. The decrease in MIB-1 labeling reached significance in adenomas exposed to quinagolide (p
ISSN:1046-3976
1559-0097
1046-3976
DOI:10.1385/EP:11:4:341