Analysis of the Cycilin D1/p16/pRb Pathway in Parathyroid Adenomas

Cyclin D1/p16/pRb pathway controlling G1-S cell cycle checkpoint is frequently altered in human tumors. Currently, scarce data are available for parathyroid tumors. We have studied 46 parathyroid adenomas (PTAs) and 12 normal parathyroid glands (PTGs) by immunohistochemistry with cyclin D1 (CD1), p1...

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Published in:Endocrine pathology 2000, Vol.11 (3), p.259-266
Main Authors: Cristobal, Eva, Arribas, Begona, Tardio, Juan, AIcazar, Jose A., Matinez-Montero, Juan C., Carrion, Rafael, Polo, Jose R., Gil, Laura, Azanedo, Marta, Rojas, Jose M., Menarguez, Javier
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Language:English
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Summary:Cyclin D1/p16/pRb pathway controlling G1-S cell cycle checkpoint is frequently altered in human tumors. Currently, scarce data are available for parathyroid tumors. We have studied 46 parathyroid adenomas (PTAs) and 12 normal parathyroid glands (PTGs) by immunohistochemistry with cyclin D1 (CD1), p16, pRb, and Ki-67 antibodies. We observed CD1 expression in 89%, p16 in 70%, and pRb in 100% of PTAs. Statistically significant differences with normal PTGs were found only concerning p16 expression (p
ISSN:1559-0097