The effect of re-operation on survival in patients with recurrent glioblastoma

Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. A retrospective analysis was performed for GBM patients followed between 01/2005...

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Bibliographic Details
Published in:Anticancer research 2015-03, Vol.35 (3), p.1743-1748
Main Authors: Franceschi, Enrico, Bartolotti, Marco, Tosoni, Alicia, Bartolini, Stefania, Sturiale, Carmelo, Fioravanti, Antonio, Pozzati, Eugenio, Galzio, Renato, Talacchi, Andrea, Volpin, Lorenzo, Morandi, Luca, Danieli, Daniela, Ermani, Mario, Brandes, Alba A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Brain Neoplasms - mortality
Brain Neoplasms - surgery
Glioblastoma - mortality
Glioblastoma - surgery
Humans
Middle Aged
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - surgery
Reoperation
Retrospective Studies
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Summary:Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. Two hundred and thirty-two patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. Second surgery might have a limited impact in the clinical course of recurrent GBM patients.
ISSN:0250-7005
1791-7530