Pulled Polymer Loops as a Model for the Alignment of Meiotic Chromosomes

During recombination, the DNA of parents exchange their genetic information to give rise to a genetically unique offspring. For recombination to occur, homologous chromosomes need to find each other and align with high precision. Fission yeast solves this problem by folding chromosomes in loops and...

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Bibliographic Details
Published in:Physical review letters 2015-11, Vol.115 (20), p.208102-208102
Main Authors: Lin, Yen Ting, Frömberg, Daniela, Huang, Wenwen, Delivani, Petrina, Chacón, Mariola, Tolić, Iva M, Jülicher, Frank, Zaburdaev, Vasily
Format: Article
Language:English
Subjects:
Alignment
Brownian motion
Chromosomes
Chromosomes, Fungal
Exchange
Genetics
Meiosis - genetics
Models, Genetic
Parents
Schizosaccharomyces - cytology
Schizosaccharomyces - genetics
Schizosaccharomyces - ultrastructure
Schizosaccharomyces pombe
Statistics
Stochastic processes
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Summary:During recombination, the DNA of parents exchange their genetic information to give rise to a genetically unique offspring. For recombination to occur, homologous chromosomes need to find each other and align with high precision. Fission yeast solves this problem by folding chromosomes in loops and pulling them through the viscous nucleoplasm. We propose a theory of pulled polymer loops to quantify the effect of drag forces on the alignment of chromosomes. We introduce an external force field to the concept of a Brownian bridge and thus solve for the statistics of loop configurations in space.
ISSN:0031-9007
1079-7114
DOI:10.1103/PhysRevLett.115.208102