Usefulness of duloxetine for Paclitaxel-induced peripheral neuropathy treatment in gynecological cancer patients

The present study aimed at evaluating the usefulness and adverse effects of duloxetine treatment for paclitaxel-induced peripheral neuropathy in gynecological cancer patients. Medical records of gynecological cancer patients treated with duloxetine were retrospectively studied to evaluate the drug&#...

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Bibliographic Details
Published in:Anticancer research 2015-01, Vol.35 (1), p.359-363
Main Authors: Otake, Akiko, Yoshino, Kiyoshi, Ueda, Yutaka, Sawada, Kenjiro, Mabuchi, Seiji, Kimura, Toshihiro, Kobayashi, Eiji, Isobe, Aki, Egawa-Takata, Tomomi, Matsuzaki, Shinya, Fujita, Masami, Kimura, Tadashi
Format: Article
Language:English
Subjects:
Adult
Aged
Analgesics - therapeutic use
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
Duloxetine Hydrochloride
Female
Humans
Middle Aged
Ovarian Neoplasms - drug therapy
Paclitaxel - adverse effects
Paclitaxel - therapeutic use
Peripheral Nervous System Diseases - chemically induced
Peripheral Nervous System Diseases - drug therapy
Retrospective Studies
Thiophenes - therapeutic use
Treatment Outcome
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Summary:The present study aimed at evaluating the usefulness and adverse effects of duloxetine treatment for paclitaxel-induced peripheral neuropathy in gynecological cancer patients. Medical records of gynecological cancer patients treated with duloxetine were retrospectively studied to evaluate the drug's efficacy for paclitaxel-induced peripheral neuropathy. RESULTS from 25 patients showed that an improved response was observed in 14 (56%). By univariate and multivariate analysis, the patient's age, tumor origin, regimen of chemotherapy, accumulated doses of paclitaxel or carboplatin, previous medication, maintenance dosage and timing of treatment with duloxetine were found not to be associated with the effectiveness of duloxetine treatment. Adverse effects with duloxetine were mild and well-tolerated. As an option, duloxetine can be effectively used for paclitaxel-induced peripheral neuropathy in patients with gynecological cancers, irrespective of patients' age, origin of the tumor, regimen of chemotherapy, or previous medication.
ISSN:0250-7005
1791-7530