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Usefulness of duloxetine for Paclitaxel-induced peripheral neuropathy treatment in gynecological cancer patients
The present study aimed at evaluating the usefulness and adverse effects of duloxetine treatment for paclitaxel-induced peripheral neuropathy in gynecological cancer patients. Medical records of gynecological cancer patients treated with duloxetine were retrospectively studied to evaluate the drug&#...
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| Published in: | Anticancer research 2015-01, Vol.35 (1), p.359-363 |
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| Main Authors: | , , , , , , , , , , , |
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| container_end_page | 363 |
| container_issue | 1 |
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| container_title | Anticancer research |
| container_volume | 35 |
| creator | Otake, Akiko Yoshino, Kiyoshi Ueda, Yutaka Sawada, Kenjiro Mabuchi, Seiji Kimura, Toshihiro Kobayashi, Eiji Isobe, Aki Egawa-Takata, Tomomi Matsuzaki, Shinya Fujita, Masami Kimura, Tadashi |
| description | The present study aimed at evaluating the usefulness and adverse effects of duloxetine treatment for paclitaxel-induced peripheral neuropathy in gynecological cancer patients.
Medical records of gynecological cancer patients treated with duloxetine were retrospectively studied to evaluate the drug's efficacy for paclitaxel-induced peripheral neuropathy.
RESULTS from 25 patients showed that an improved response was observed in 14 (56%). By univariate and multivariate analysis, the patient's age, tumor origin, regimen of chemotherapy, accumulated doses of paclitaxel or carboplatin, previous medication, maintenance dosage and timing of treatment with duloxetine were found not to be associated with the effectiveness of duloxetine treatment. Adverse effects with duloxetine were mild and well-tolerated.
As an option, duloxetine can be effectively used for paclitaxel-induced peripheral neuropathy in patients with gynecological cancers, irrespective of patients' age, origin of the tumor, regimen of chemotherapy, or previous medication. |
| format | article |
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Medical records of gynecological cancer patients treated with duloxetine were retrospectively studied to evaluate the drug's efficacy for paclitaxel-induced peripheral neuropathy.
RESULTS from 25 patients showed that an improved response was observed in 14 (56%). By univariate and multivariate analysis, the patient's age, tumor origin, regimen of chemotherapy, accumulated doses of paclitaxel or carboplatin, previous medication, maintenance dosage and timing of treatment with duloxetine were found not to be associated with the effectiveness of duloxetine treatment. Adverse effects with duloxetine were mild and well-tolerated.
As an option, duloxetine can be effectively used for paclitaxel-induced peripheral neuropathy in patients with gynecological cancers, irrespective of patients' age, origin of the tumor, regimen of chemotherapy, or previous medication.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 25550572</identifier><language>eng</language><publisher>Greece</publisher><subject>Adult ; Aged ; Analgesics - therapeutic use ; Antineoplastic Agents, Phytogenic - adverse effects ; Antineoplastic Agents, Phytogenic - therapeutic use ; Duloxetine Hydrochloride ; Female ; Humans ; Middle Aged ; Ovarian Neoplasms - drug therapy ; Paclitaxel - adverse effects ; Paclitaxel - therapeutic use ; Peripheral Nervous System Diseases - chemically induced ; Peripheral Nervous System Diseases - drug therapy ; Retrospective Studies ; Thiophenes - therapeutic use ; Treatment Outcome</subject><ispartof>Anticancer research, 2015-01, Vol.35 (1), p.359-363</ispartof><rights>Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25550572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otake, Akiko</creatorcontrib><creatorcontrib>Yoshino, Kiyoshi</creatorcontrib><creatorcontrib>Ueda, Yutaka</creatorcontrib><creatorcontrib>Sawada, Kenjiro</creatorcontrib><creatorcontrib>Mabuchi, Seiji</creatorcontrib><creatorcontrib>Kimura, Toshihiro</creatorcontrib><creatorcontrib>Kobayashi, Eiji</creatorcontrib><creatorcontrib>Isobe, Aki</creatorcontrib><creatorcontrib>Egawa-Takata, Tomomi</creatorcontrib><creatorcontrib>Matsuzaki, Shinya</creatorcontrib><creatorcontrib>Fujita, Masami</creatorcontrib><creatorcontrib>Kimura, Tadashi</creatorcontrib><title>Usefulness of duloxetine for Paclitaxel-induced peripheral neuropathy treatment in gynecological cancer patients</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The present study aimed at evaluating the usefulness and adverse effects of duloxetine treatment for paclitaxel-induced peripheral neuropathy in gynecological cancer patients.
Medical records of gynecological cancer patients treated with duloxetine were retrospectively studied to evaluate the drug's efficacy for paclitaxel-induced peripheral neuropathy.
RESULTS from 25 patients showed that an improved response was observed in 14 (56%). By univariate and multivariate analysis, the patient's age, tumor origin, regimen of chemotherapy, accumulated doses of paclitaxel or carboplatin, previous medication, maintenance dosage and timing of treatment with duloxetine were found not to be associated with the effectiveness of duloxetine treatment. Adverse effects with duloxetine were mild and well-tolerated.
As an option, duloxetine can be effectively used for paclitaxel-induced peripheral neuropathy in patients with gynecological cancers, irrespective of patients' age, origin of the tumor, regimen of chemotherapy, or previous medication.</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesics - therapeutic use</subject><subject>Antineoplastic Agents, Phytogenic - adverse effects</subject><subject>Antineoplastic Agents, Phytogenic - therapeutic use</subject><subject>Duloxetine Hydrochloride</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - drug therapy</subject><subject>Paclitaxel - adverse effects</subject><subject>Paclitaxel - therapeutic use</subject><subject>Peripheral Nervous System Diseases - chemically induced</subject><subject>Peripheral Nervous System Diseases - drug therapy</subject><subject>Retrospective Studies</subject><subject>Thiophenes - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqF0DtPwzAUBeAIgWgp_AXkkSXS9St2RlTxkirBQOfIja9bI8cJdiK1_55IlJnpDOfTGc5FsaSqpqWSHC6LJTAJpQKQi-Im5y-Aqqo1vy4WTEoJUrFlMWwzuilEzJn0jtgp9EccfUTi-kQ-TBv8aI4YSh_t1KIlAyY_HDCZQCJOqR_MeDiRMaEZO4wj8ZHsTxHbPvR7386qNbHFRGbn5z7fFlfOhIx351wV2-enz_VruXl_eVs_bso9q-qxROZ2UmsKHLhmglaMQq3QOboT4IQFZimXFDlQY6W2iklDHVRMGMmsEnxVPPzuDqn_njCPTedziyGYiP2UG6plLVQNoP-nlaCCVVrwmd6f6bTr0DZD8p1Jp-bvUP4DAOZzuA</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Otake, Akiko</creator><creator>Yoshino, Kiyoshi</creator><creator>Ueda, Yutaka</creator><creator>Sawada, Kenjiro</creator><creator>Mabuchi, Seiji</creator><creator>Kimura, Toshihiro</creator><creator>Kobayashi, Eiji</creator><creator>Isobe, Aki</creator><creator>Egawa-Takata, Tomomi</creator><creator>Matsuzaki, Shinya</creator><creator>Fujita, Masami</creator><creator>Kimura, Tadashi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201501</creationdate><title>Usefulness of duloxetine for Paclitaxel-induced peripheral neuropathy treatment in gynecological cancer patients</title><author>Otake, Akiko ; Yoshino, Kiyoshi ; Ueda, Yutaka ; Sawada, Kenjiro ; Mabuchi, Seiji ; Kimura, Toshihiro ; Kobayashi, Eiji ; Isobe, Aki ; Egawa-Takata, Tomomi ; Matsuzaki, Shinya ; Fujita, Masami ; Kimura, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g269t-e2fb588103038241621097eff1b40f4d02d1351e301ad58d725a1f0624a52d743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesics - therapeutic use</topic><topic>Antineoplastic Agents, Phytogenic - adverse effects</topic><topic>Antineoplastic Agents, Phytogenic - therapeutic use</topic><topic>Duloxetine Hydrochloride</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Ovarian Neoplasms - drug therapy</topic><topic>Paclitaxel - adverse effects</topic><topic>Paclitaxel - therapeutic use</topic><topic>Peripheral Nervous System Diseases - chemically induced</topic><topic>Peripheral Nervous System Diseases - drug therapy</topic><topic>Retrospective Studies</topic><topic>Thiophenes - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otake, Akiko</creatorcontrib><creatorcontrib>Yoshino, Kiyoshi</creatorcontrib><creatorcontrib>Ueda, Yutaka</creatorcontrib><creatorcontrib>Sawada, Kenjiro</creatorcontrib><creatorcontrib>Mabuchi, Seiji</creatorcontrib><creatorcontrib>Kimura, Toshihiro</creatorcontrib><creatorcontrib>Kobayashi, Eiji</creatorcontrib><creatorcontrib>Isobe, Aki</creatorcontrib><creatorcontrib>Egawa-Takata, Tomomi</creatorcontrib><creatorcontrib>Matsuzaki, Shinya</creatorcontrib><creatorcontrib>Fujita, Masami</creatorcontrib><creatorcontrib>Kimura, Tadashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otake, Akiko</au><au>Yoshino, Kiyoshi</au><au>Ueda, Yutaka</au><au>Sawada, Kenjiro</au><au>Mabuchi, Seiji</au><au>Kimura, Toshihiro</au><au>Kobayashi, Eiji</au><au>Isobe, Aki</au><au>Egawa-Takata, Tomomi</au><au>Matsuzaki, Shinya</au><au>Fujita, Masami</au><au>Kimura, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of duloxetine for Paclitaxel-induced peripheral neuropathy treatment in gynecological cancer patients</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2015-01</date><risdate>2015</risdate><volume>35</volume><issue>1</issue><spage>359</spage><epage>363</epage><pages>359-363</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>The present study aimed at evaluating the usefulness and adverse effects of duloxetine treatment for paclitaxel-induced peripheral neuropathy in gynecological cancer patients.
Medical records of gynecological cancer patients treated with duloxetine were retrospectively studied to evaluate the drug's efficacy for paclitaxel-induced peripheral neuropathy.
RESULTS from 25 patients showed that an improved response was observed in 14 (56%). By univariate and multivariate analysis, the patient's age, tumor origin, regimen of chemotherapy, accumulated doses of paclitaxel or carboplatin, previous medication, maintenance dosage and timing of treatment with duloxetine were found not to be associated with the effectiveness of duloxetine treatment. Adverse effects with duloxetine were mild and well-tolerated.
As an option, duloxetine can be effectively used for paclitaxel-induced peripheral neuropathy in patients with gynecological cancers, irrespective of patients' age, origin of the tumor, regimen of chemotherapy, or previous medication.</abstract><cop>Greece</cop><pmid>25550572</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Anticancer research, 2015-01, Vol.35 (1), p.359-363 |
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| language | eng |
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| subjects | Adult Aged Analgesics - therapeutic use Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - therapeutic use Duloxetine Hydrochloride Female Humans Middle Aged Ovarian Neoplasms - drug therapy Paclitaxel - adverse effects Paclitaxel - therapeutic use Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - drug therapy Retrospective Studies Thiophenes - therapeutic use Treatment Outcome |
| title | Usefulness of duloxetine for Paclitaxel-induced peripheral neuropathy treatment in gynecological cancer patients |
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