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Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma
Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types. Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy....
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| Published in: | Anticancer research 2015-06, Vol.35 (6), p.3571-3574 |
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| container_end_page | 3574 |
| container_issue | 6 |
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| container_title | Anticancer research |
| container_volume | 35 |
| creator | Rades, Dirk Huttenlocher, Stefan Gebauer, Niklas Hornung, Dagmar Trang, Ngo Thuy Khoa, Mai Trong Schild, Steven E |
| description | Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types.
Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.
SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p |
| format | article |
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Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.
SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006).
In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 26026128</identifier><language>eng</language><publisher>Greece</publisher><subject>Aged ; Brain Neoplasms - pathology ; Brain Neoplasms - secondary ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - radiotherapy ; Female ; Humans ; Kaplan-Meier Estimate ; Karnofsky Performance Status ; Male ; Middle Aged ; Neoplasms, Radiation-Induced - pathology ; Neoplasms, Radiation-Induced - secondary ; Proportional Hazards Models ; Radiosurgery - adverse effects ; Radiotherapy Dosage</subject><ispartof>Anticancer research, 2015-06, Vol.35 (6), p.3571-3574</ispartof><rights>Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26026128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rades, Dirk</creatorcontrib><creatorcontrib>Huttenlocher, Stefan</creatorcontrib><creatorcontrib>Gebauer, Niklas</creatorcontrib><creatorcontrib>Hornung, Dagmar</creatorcontrib><creatorcontrib>Trang, Ngo Thuy</creatorcontrib><creatorcontrib>Khoa, Mai Trong</creatorcontrib><creatorcontrib>Schild, Steven E</creatorcontrib><title>Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types.
Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.
SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006).
In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.</description><subject>Aged</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - secondary</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - radiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Karnofsky Performance Status</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Radiation-Induced - pathology</subject><subject>Neoplasms, Radiation-Induced - secondary</subject><subject>Proportional Hazards Models</subject><subject>Radiosurgery - adverse effects</subject><subject>Radiotherapy Dosage</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMobl39C5Kjl0I-m_Qoix8LC170XNJkIpW2qUl62H9vFtezzPAOMzy8vMwFqqhqaa0kJ5eoIkySWhEiN-gmpS9CmqbV_BptWENYQ5mukNtPi7EZB49Thgghl22wOBo3hLTGT4hH7EICHGZsw5xjGE-wLWwfzYgnyCaVhoR9DBOOMJerhbGIiXaYw2Ru0ZU3Y4K789yij-en991rfXh72e8eD_XChMgltfNOtYwwa32vtPLaCW571WrLnCwqLZRyFLQE0gL1FKjlfQtE9dTxLXr49V1i-F4h5W4a0imKmSGsqaNatkJT3aj_0UYLwQWXJ_T-jK79BK5b4jCZeOz-nsh_AD8mcMM</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Rades, Dirk</creator><creator>Huttenlocher, Stefan</creator><creator>Gebauer, Niklas</creator><creator>Hornung, Dagmar</creator><creator>Trang, Ngo Thuy</creator><creator>Khoa, Mai Trong</creator><creator>Schild, Steven E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201506</creationdate><title>Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma</title><author>Rades, Dirk ; Huttenlocher, Stefan ; Gebauer, Niklas ; Hornung, Dagmar ; Trang, Ngo Thuy ; Khoa, Mai Trong ; Schild, Steven E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p244t-75dfd79202ccfb787f8d43cb798c2d598c5cececd1e85e09e1f1e1c3b9e07b1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - secondary</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - radiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Karnofsky Performance Status</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Radiation-Induced - pathology</topic><topic>Neoplasms, Radiation-Induced - secondary</topic><topic>Proportional Hazards Models</topic><topic>Radiosurgery - adverse effects</topic><topic>Radiotherapy Dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rades, Dirk</creatorcontrib><creatorcontrib>Huttenlocher, Stefan</creatorcontrib><creatorcontrib>Gebauer, Niklas</creatorcontrib><creatorcontrib>Hornung, Dagmar</creatorcontrib><creatorcontrib>Trang, Ngo Thuy</creatorcontrib><creatorcontrib>Khoa, Mai Trong</creatorcontrib><creatorcontrib>Schild, Steven E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rades, Dirk</au><au>Huttenlocher, Stefan</au><au>Gebauer, Niklas</au><au>Hornung, Dagmar</au><au>Trang, Ngo Thuy</au><au>Khoa, Mai Trong</au><au>Schild, Steven E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2015-06</date><risdate>2015</risdate><volume>35</volume><issue>6</issue><spage>3571</spage><epage>3574</epage><pages>3571-3574</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types.
Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.
SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006).
In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.</abstract><cop>Greece</cop><pmid>26026128</pmid><tpages>4</tpages></addata></record> |
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| subjects | Aged Brain Neoplasms - pathology Brain Neoplasms - secondary Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - radiotherapy Female Humans Kaplan-Meier Estimate Karnofsky Performance Status Male Middle Aged Neoplasms, Radiation-Induced - pathology Neoplasms, Radiation-Induced - secondary Proportional Hazards Models Radiosurgery - adverse effects Radiotherapy Dosage |
| title | Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma |
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