Effects of adrenaline on circulatory dynamics and cardiac function in rats administered chlorpromazine

[Abstract] We aimed to elucidate changes in circulatory dynamics and cardiac function during concomitant use of chlorpromazine (CPZ) and adrenaline (AD). An arterial line and left intraventricular pressure-volume measurement catheter were inserted in rats. CPZ 10 mg/kg was administered to the left g...

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Bibliographic Details
Published in:Odontology 2017-01, Vol.105 (1), p.103-107
Main Authors: Sakai, Arisa, Sunada, Katsuhisa
Format: Article
Language:English
Subjects:
Animals
Blood pressure
Catheters
Chlorpromazine - administration & dosage
Chlorpromazine - pharmacology
Dentistry
Drug therapy
Epinephrine - administration & dosage
Epinephrine - pharmacology
Heart Function Tests
Hemodynamics - drug effects
Male
Medicine
Oral and Maxillofacial Surgery
Original Article
Rats
Rats, Wistar
Rodents
Veins & arteries
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Summary:[Abstract] We aimed to elucidate changes in circulatory dynamics and cardiac function during concomitant use of chlorpromazine (CPZ) and adrenaline (AD). An arterial line and left intraventricular pressure-volume measurement catheter were inserted in rats. CPZ 10 mg/kg was administered to the left great adductor muscle, followed by normal saline (NS) or AD 50 μg/kg through the tongue 20 min later. End-diastolic volume (Ved), end-systolic pressure (Pes), stroke volume (SV), stroke work (SW), end-systolic volume elastance (Ees), systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR) were measured. Following AD administration, Ved significantly decreased at 2-4 and 10 min than that in control rats ; Pes significantly decreased at 1 min ; Ees significantly increased from 2 to 10 min ; SV did not change significantly, and SW significantly reduced at 1 and 2 min ; SBP and DBP were lower at 1-3 min than in the control ; and PR increased at 10 min. These findings suggest that when AD-containing local anesthetics are administered during dental treatment of patients taking CPZ, there is a risk of a temporary drop in blood pressure. However, the blood pressure is recovered a few minutes later by the increase in afterload and the myocardial contractile force.
ISSN:1618-1247
1618-1255
DOI:10.1007/s10266-016-0241-x