Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti‐HBs in a population in Northeastern Brazil

Mutations in the a determinant of S gene may develop co‐existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti‐HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of ne...

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Published in:Journal of medical virology 2017-03, Vol.89 (3), p.458-462
Main Authors: de Campos Albuquerque, Ingrid, Sousa, Marinilde Teles, Santos, Max Diego Cruz, Nunes, Jomar Diogo Costa, Moraes, Maria Josélia Diniz, Gomes‐Gouvêa, Michele Soares, Pinho, João Renato Rebelo, Carrilho, Flair José, Fonseca, Lena Maria Barros, de Sousa Paiva Ferreira, Adalgisa
Format: Article
Language:English
Subjects:
Adult
antibody
Brazil - epidemiology
Cross-Sectional Studies
DNA, Viral - blood
Female
HBsAg
hepatitis B
Hepatitis B - diagnosis
Hepatitis B - epidemiology
Hepatitis B - virology
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Hepatitis B Surface Antigens - genetics
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Humans
Male
Middle Aged
Mutation
Sequence Analysis, DNA
Seroepidemiologic Studies
Viral Load
Virology
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Summary:Mutations in the a determinant of S gene may develop co‐existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti‐HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of neutralizing action of anti‐HBs antibodies. This study identified individuals with concomitant HBsAg and anti‐HBs serological markers in individuals of Maranhão, Northeastern Brazil. Samples from a population‐based study were evaluated for HBsAg, anti‐HBs, and anti‐HBc, and those that tested positive for simultaneous HBsAg and anti‐HBs were submitted to HBV DNA quantification and S gene characterization by Sanger sequencing. Mutations were investigated in the a determinant located in major hydrophilic region (MHR) of the S gene. Among 3,984 samples analyzed, 92 (2.3%) were positive for HBsAg and three had the atypical HBsAg and anti‐HBs‐positive profile (3.26%). The frequency of HBsAg and anti‐HBs co‐existence was similar to previous studies. Only one individual harbored mutation in the S gene a determinant associated with this profile. Little is known about this phenomenon; however, studies as ours may contribute for future enlightenment of this important issue. J. Med. Virol. 89:458–462, 2017. © 2016 Wiley Periodicals, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24653