Genetic, Immune-Inflammatory, and Oxidative Stress Biomarkers as Predictors for Disability and Disease Progression in Multiple Sclerosis

• Published in: Molecular neurobiology 2017, Vol.54 (1), p.31-44
• Main Authors: Kallaur, Ana Paula, Reiche, Edna Maria Vissoci, Oliveira, Sayonara Rangel, Simão, Andrea Name Colado, Pereira, Wildea Lice de Carvalho Jennings, Alfieri, Daniela Frizon, Flauzino, Tamires, Proença, Caio de Meleck, Lozovoy, Marcell Alysson Batisti, Kaimen-Maciel, Damacio Ramón, Maes, Michael
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cytokines; Disabled Persons; Disease; Disease Progression; Female; Genetic Markers - physiology; Health sciences; Humans; Inflammation Mediators - blood; Male; Middle Aged; Multiple sclerosis; Multiple Sclerosis - blood; Multiple Sclerosis - diagnosis; Multiple Sclerosis - genetics; Neurobiology; Neurology; Neurosciences; Oxidative stress; Oxidative Stress - physiology; Pathogenesis; Pathology; Polymorphism; Predictive Value of Tests; Proteins; Retrospective Studies; Spinal cord; Tumor necrosis factor-TNF
• ISSN: 0893-7648; 1559-1182
• DOI: 10.1007/s12035-015-9648-6

The aim of this study was to evaluate the TNFβ Nco I polymorphism (rs909253) and immune-inflammatory, oxidative, and nitrosative stress (IO&NS) biomarkers as predictors of disease progression in multiple sclerosis (MS). We included 212 MS patients (150 female, 62 male, mean (±standard deviation (SD)) age = 42.7 ± 13.8 years) and 249 healthy controls (177 female, 72 male, 36.8 ± 11 years). The disability was measured the Expanded Disability Status Scale (EDSS) in 2006 and 2011. We determined the TNFβ Nco I polymorphism and serum levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-4, IL-10, and IL-17, albumin, ferritin, and plasma levels of lipid hydroperoxides (CL-LOOH), carbonyl protein, advanced oxidation protein products (AOPPs), nitric oxide metabolites (NOx), and total radical-trapping antioxidant parameter (TRAP). The mean EDSS (±SD) in 2006 was 1.62 ± 2.01 and in 2011 3.16 ± 2.29, and disease duration was 7.34 ± 7.0 years. IL-10, TNF-α, IFN-γ, AOPP, and NOx levels were significantly higher and IL-4 lower in MS patients with a higher 2011 EDSS scores (≥3) as compared with those with EDSS