Relation of Mitochondrial DNA Copy Number in Peripheral Blood to Postoperative Atrial Fibrillation After Isolated Off-Pump Coronary Artery Bypass Grafting

Oxidative stress has been considered to be an important factor contributing to postoperative atrial fibrillation (PoAF). Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be associated with a patient's oxidative stress. Therefore, we sought to determine whether there w...

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Bibliographic Details
Published in:The American journal of cardiology 2017-02, Vol.119 (3), p.473-477
Main Authors: Zhang, Jian, MD, Xu, Shu, MD, Xu, Yinli, MS, Liu, Yu, MD, Li, Zhi, MD, Zhang, Yuji, MD, Jin, Yan, MD, Xue, Xiaodong, MD, PhD, Wang, Huishan, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - blood
Atrial Fibrillation - epidemiology
Blood products
Cardiac arrhythmia
Cardiovascular
Cardiovascular disease
Chronic obstructive pulmonary disease
Confidence intervals
Coronary Artery Bypass, Off-Pump
Coronary Artery Disease - surgery
Coronary vessels
Deoxyribonucleic acid
Diabetes
DNA
DNA, Mitochondrial - blood
Female
Heart attacks
Heart surgery
Humans
Hypertension
Incidence
Intensive care
Lipid peroxidation
Logistic Models
Logistics
Male
Middle Aged
Mitochondrial DNA
Multivariate Analysis
Neutrophils
Oxidative Stress
Postoperative Complications - blood
Postoperative Complications - epidemiology
Proportional Hazards Models
Real-Time Polymerase Chain Reaction
Regression analysis
Retrospective Studies
Risk Factors
Standard deviation
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Summary:Oxidative stress has been considered to be an important factor contributing to postoperative atrial fibrillation (PoAF). Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be associated with a patient's oxidative stress. Therefore, we sought to determine whether there was association between mtDNA copy number and the onset of atrial fibrillation. mtDNA copy numbers were measured using the quantitative real-time polymerase chain reaction in peripheral blood from 485 consecutive patients with sinus rhythm undergoing coronary artery bypass grafting. The blood was collected before surgery. In the cohort, the incidence of PoAF was 20.8% (101/485). The mean mtDNA copy number was significantly higher in patents with PoAF than in those with sinus rhythm (36.43 vs 16.63, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.10.017