Biomonitoring of gasoline station attendants exposed to benzene: Effect of gender

•Gender influences on some alterations caused by occupational benzene exposure.•Gender alters the biotransformation of benzene to trans, trans-muconic acid.•Women may be more susceptible to blood alterations caused by benzene exposure.•These data contribute to the development of specific standards t...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2017-01, Vol.813, p.1-9
Main Authors: Moro, Angela M., Brucker, Natália, Charão, Mariele F., Baierle, Marília, Sauer, Elisa, Goethel, Gabriela, Barth, Anelise, Nascimento, Sabrina N., Gauer, Bruna, Durgante, Juliano, Amaral, Beatriz S., Neto, Francisco R.A., Gioda, Adriana, Garcia, Solange C.
Format: Article
Language:English
Subjects:
Gasoline station attendants
Gender
Genotoxicity
Hematotoxicity
Non-cancer effects
Occupational benzene exposure
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Summary:•Gender influences on some alterations caused by occupational benzene exposure.•Gender alters the biotransformation of benzene to trans, trans-muconic acid.•Women may be more susceptible to blood alterations caused by benzene exposure.•These data contribute to the development of specific standards to women protection. Women are employed in increasing numbers as gasoline station attendants, a work category with risk of exposure to benzene. We have assessed the effect of gender on biomarkers of occupational benzene exposure. Gasoline station attendants (20 men and 20 women) and 40 control individuals (20 men and 20 women) with no history of occupational benzene exposure were evaluated. Benzene exposure was monitoring by environmental and biological measurements. Urinary trans,trans-muconic acid levels, well-known genetic and hematological alterations linked to benzene exposure, and non-cancer effects on the immune, hepatic, and renal systems were investigated. Our results suggest a potential effect of gender on some effects of occupational benzene exposure, particularly the hematological parameters and trans,trans-muconic acid levels. Despite limitations of our study, our findings provide important considerations about occupational exposure of women to benzene and may contribute to the development of occupational protection standards.
ISSN:1383-5718
1879-3592
DOI:10.1016/j.mrgentox.2016.11.002