Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression

Highlights • Cytoskeletal remodeling induced by amitriptyline in the CA3 region. • Neuronal plasticity is a pharmacological target of amitriptyline. • Hippocampal alterations of the p-NFH appeared associated with the mechanism of amitriptyline.

Saved in:
Bibliographic Details
Published in:Brain research bulletin 2017-01, Vol.128, p.1-6
Main Authors: Sanna, Maria Domenica, Ghelardini, Carla, Galeotti, Nicoletta
Format: Article
Language:English
Subjects:
Acute Disease
Amitriptyline
Amitriptyline - pharmacology
Animals
Antidepressive Agents, Tricyclic - pharmacology
CA3 Region, Hippocampal - drug effects
CA3 Region, Hippocampal - metabolism
CA3 Region, Hippocampal - pathology
Chronic Disease
Citalopram - pharmacology
Depression
Depressive Disorder - drug therapy
Depressive Disorder - metabolism
Depressive Disorder - pathology
Disease Models, Animal
Hippocampal CA3 region
Male
Mice
Neurofilament Proteins - metabolism
Neurofilament-H
Neurology
Phosphorylation - drug effects
Random Allocation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Cytoskeletal remodeling induced by amitriptyline in the CA3 region. • Neuronal plasticity is a pharmacological target of amitriptyline. • Hippocampal alterations of the p-NFH appeared associated with the mechanism of amitriptyline.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2016.11.001