The efficacy of amoxicillin sodium against streptococcosis in cultured olive flounder Paralichthys olivaceus and its pharmacokinetics

• Published in: Journal of veterinary pharmacology and therapeutics 2017-01, Vol.40 (1), p.77-87
• Main Authors: Lim, J.‐W., Jung, M.‐H., Jung, S.‐J., Kim, D.‐H., Park, K. H., Kang, S. Y.
• Format: Article
• Language: English
• Subjects: Amoxicillin - administration & dosage; Amoxicillin - pharmacokinetics; Amoxicillin - therapeutic use; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Aquaculture - methods; Fish Diseases - drug therapy; Flounder - microbiology; Injections, Intramuscular - veterinary; Paralichthys olivaceus; Pleuronectiformes; Streptococcal Infections - drug therapy; Streptococcal Infections - veterinary; Streptococcus; Streptococcus - drug effects; Streptococcus iniae; Streptococcus iniae - drug effects
• ISSN: 0140-7783; 1365-2885
• DOI: 10.1111/jvp.12321

The efficacy of amoxicillin sodium for controlling field and experimental Streptococcus iniae and S. parauberis infections in olive flounder (Paralichthys olivaceus) was evaluated after a single intramuscular administration. Furthermore, the minimal inhibitory concentrations (MIC) against 21 Streptococcus strains were determined. In addition, the pharmacokinetics and residue depletion in olive flounder were investigated. Single intramuscular doses of amoxicillin sodium at 20, 40, 80, and 160 mg/kg b.w. fish significantly reduced cumulative mortality rates to 18.8–31.3% (P