Bone Formation in the Context of Growth Retardation Induced by hIGFBP-1 Overexpression in Transgenic Mice

In humans, intrauterine growth retardation (hIUGR) is correlated with an overexpression of insulin-like growthfactor binding protein 1 (IGFBP-1). The affected children also present a delay in bone mineralization. In this study, transgenic 12-day-old mutant mice overexpressing human IGFBP-1 hepatospe...

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Bibliographic Details
Published in:Connective tissue research 2002, Vol.43 (2-3), p.515-519
Main Authors: Ben Lagha, N., Menuelle, P., Seurin, D., Binoux, M., Lebouc, Y., Berdal, A.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Bone
Bone Density
Growth Disorders - chemically induced
Growth Disorders - diagnostic imaging
Growth Disorders - physiopathology
Growth Retardation
Higfbp-1
Humans
Insulin-Like Growth Factor Binding Protein 1 - genetics
Mice
Mice, Transgenic - genetics
Osteogenesis
Overexpression
Radiography
Transgenic Mice
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Summary:In humans, intrauterine growth retardation (hIUGR) is correlated with an overexpression of insulin-like growthfactor binding protein 1 (IGFBP-1). The affected children also present a delay in bone mineralization. In this study, transgenic 12-day-old mutant mice overexpressing human IGFBP-1 hepatospecifically showed a severe growth retardation. Alcian blue and alizarin red S staining of the skeleton revealed mineralization defects at the posterior level of the skull (delayed suture closure) and in appendicular and axial skeleton. Furthermore, microradiographic analysis showed a reduced bone density in the same areas. Thus, overexpressing of hIGFBP-1 demonstrates early postnatal life growth retardation and a delay in mineralization in transgenic mutant mice. These data show the involvement of the IGF/IGFBP system and more particularly IGFBP-1 in the biomineralization process.
ISSN:0300-8207
1607-8438
DOI:10.1080/03008200290000998