Feasibility of triphasic CT with a modified two-point Patlak plot to determine spit kidney glomerular filtration rate in clinical practice

• Published in: Abdominal imaging 2017, Vol.42 (1), p.226-235
• Main Authors: Zhang, Yu-Dong, Xue, Chen-Qi, Wu, Chen-Jiang, Tao, Jun, Zhou, Wan-Li, Shi, Hai-Bin
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Animals; Child; Contrast Media; Feasibility Studies; Female; Gastroenterology; Glomerular Filtration Rate; Hepatology; Humans; Imaging; Iohexol - analogs & derivatives; Kidney - diagnostic imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Prospective Studies; Rabbits; Radiographic Image Interpretation, Computer-Assisted; Radiology; Retrospective Studies; Tomography, X-Ray Computed - methods
• ISSN: 2366-004X; 2366-0058
• DOI: 10.1007/s00261-016-0858-9

Purpose To investigate whether triphasic CT with a simplified Patlak plot can be used in clinical practice for the estimate of split kidney glomerular filtration rate (SKGFR). Materials and methods The animal experiment included 15 rabbits that underwent 40 dynamic contrast-enhanced CT scans of the kidneys with 1.5 s time interval. Patlak-derived SKGFR was obtained using standard forty-point, two-point (unenhanced phase, arterial phase t α, and portovenous phase t β ), and a modified two-point (MTP) (unenhanced, t α , t β , and a virtual t τ [ t τ  = ( t α  +  t β )/2]) image data, respectively. The MTP-Patlak plot approach was then validated in 13 patients who underwent a triphasic renal contrast-enhanced CT examination. SKGFR measured by 99 m Tc-DTPA clearance was as a standard reference. Results MTP-Patlak significantly reduced input function errors than two-point Patlak (21.1 ± 16.2 % vs 30.8 ± 15.2 %, p