Cognitive impairment predicts disability progression and cortical thinning in MS: An 8-year study

Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS). Although cognitive impairment (CI) affects a large proportion of MS patients, only few data are available about its prognostic value associated with advanced magnetic resonance imaging (MRI)...

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Bibliographic Details
Published in:Multiple sclerosis 2017-05, Vol.23 (6), p.848-854
Main Authors: Pitteri, Marco, Romualdi, Chiara, Magliozzi, Roberta, Monaco, Salvatore, Calabrese, Massimiliano
Format: Article
Language:English
Subjects:
Adult
Central nervous system
Cerebral Cortex - diagnostic imaging
Cognitive ability
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Cortex
Disease Progression
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Multiple Sclerosis, Relapsing-Remitting - physiopathology
NMR
Nuclear magnetic resonance
Prognosis
Severity of Illness Index
Thinning
Young Adult
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Summary:Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS). Although cognitive impairment (CI) affects a large proportion of MS patients, only few data are available about its prognostic value associated with advanced magnetic resonance imaging (MRI) metrics. Objectives: We aimed at investigating the relationship between the early CI and the disease progression over 8-year follow-up in MS patients. Methods: We conducted a retrospective 8-year longitudinal study involving 78 patients with relapsing-remitting MS, who completed neuropsychological examination and structural MRI at the time of diagnosis. Each patient was clinically evaluated every 6 months, and cortical thickness was quantified at baseline and at the end of the follow-up. Patients were classified as having normal cognition and mild or severe CI. Results: The results show that CI at the time of diagnosis is a good predictor of conversion to definite MS (p 
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458516665496