Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials

Purpose High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and syn...

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Bibliographic Details
Published in:European journal of nutrition 2018-02, Vol.57 (1), p.95-106
Main Authors: Nikbakht, Elham, Khalesi, Saman, Singh, Indu, Williams, Lauren Therese, West, Nicholas P., Colson, Natalie
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Blood Glucose - analysis
Chemistry
Chemistry and Materials Science
Chronic illnesses
Controlled Clinical Trials as Topic
Diabetes mellitus
Evidence-based medicine
Fasting
Humans
Hyperglycemia
Hyperglycemia - prevention & control
MEDLINE
Meta-analysis
Middle Aged
Nursing
Nutrition
Original Contribution
Probiotics
Probiotics - administration & dosage
Randomized Controlled Trials as Topic
Reviews
Species
Statistical analysis
Supplements
Synbiotics - administration & dosage
Systematic review
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Summary:Purpose High fasting blood glucose (FBG) can lead to chronic diseases such as diabetes mellitus, cardiovascular and kidney diseases. Consuming probiotics or synbiotics may improve FBG. A systematic review and meta-analysis of controlled trials was conducted to clarify the effect of probiotic and synbiotic consumption on FBG levels. Methods PubMed, Scopus, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched for relevant studies based on eligibility criteria. Randomized or non-randomized controlled trials which investigated the efficacy of probiotics or synbiotics on the FBG of adults were included. Studies were excluded if they were review articles and study protocols, or if the supplement dosage was not clearly mentioned. Results A total of fourteen studies (eighteen trials) were included in the analysis. Random-effects meta-analyses were conducted for the mean difference in FBG. Overall reduction in FBG observed from consumption of probiotics and synbiotics was borderline statistically significant (−0.18 mmol/L 95 % CI −0.37, 0.00; p  = 0.05). Neither probiotic nor synbiotic subgroup analysis revealed a significant reduction in FBG. The result of subgroup analysis for baseline FBG level ≥7 mmol/L showed a reduction in FBG of 0.68 mmol/L (−1.07, −0.29 ; ρ  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-016-1300-3