Human cytomegalovirus downregulates SLITRK6 expression through IE2

Congenital human cytomegalovirus (HCMV) infection causes sensorineural hearing loss (SNHL) and other neurological disorders, although the neuropathogenesis of HCMV infection is not well understood. Here, we show that the expression of SLITRK6 , one of causative genes for hereditary SNHL, was robustl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurovirology 2017-02, Vol.23 (1), p.79-86
Main Authors: Liao, Huanan, Sato, Haruna, Chiba, Ryosuke, Kawai, Tomoko, Nakabayashi, Kazuhiko, Hata, Kenichiro, Akutsu, Hidenori, Fujiwara, Shigeyoshi, Nakamura, Hiroyuki
Format: Article
Language:English
Subjects:
Astrocytes - metabolism
Astrocytes - pathology
Astrocytes - virology
Biomedical and Life Sciences
Biomedicine
Cell Line
Cell Line, Tumor
Cytomegalovirus - genetics
Cytomegalovirus - growth & development
Cytomegalovirus - pathogenicity
Fibroblasts - metabolism
Fibroblasts - pathology
Fibroblasts - virology
Gene Expression Regulation
Hearing Loss, Sensorineural - pathology
Hearing Loss, Sensorineural - virology
Host-Pathogen Interactions
Humans
Immediate-Early Proteins - genetics
Immediate-Early Proteins - metabolism
Immunology
Induced Pluripotent Stem Cells - metabolism
Induced Pluripotent Stem Cells - pathology
Induced Pluripotent Stem Cells - virology
Infectious Diseases
Membrane Proteins - genetics
Membrane Proteins - metabolism
Neuroglia - metabolism
Neuroglia - pathology
Neuroglia - virology
Neurology
Neurosciences
Signal Transduction
Trans-Activators - genetics
Trans-Activators - metabolism
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Congenital human cytomegalovirus (HCMV) infection causes sensorineural hearing loss (SNHL) and other neurological disorders, although the neuropathogenesis of HCMV infection is not well understood. Here, we show that the expression of SLITRK6 , one of causative genes for hereditary SNHL, was robustly downregulated by HCMV infection in cultured neural cells. We also show that HCMV-encoded immediate-early 2 (IE2) proteins mediate this downregulation and their carboxy-terminal region, especially amino acid residue Gln 548 , has a critical role. These findings suggest that the downregulation of SLITRK6 expression by IE2 may have a role in HCMV-induced SNHL and other neurological disorders.
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-016-0475-y